Since the discovery of the genetic bases of the long QT syndrome, several new genetically
mediated arrhythmias have been described, defining a new group of syndromes, called …

Inheritable cardiac disorders, which may be associated with cardiomyopathic changes, are
often associated with increased risk of sudden death in the young. Early linkage analysis …

This review summarizes data in support of the notion that the cardiac intercalated disc is the
host of a protein interacting network, called “the connexome”, where molecules classically …

Background—The management of long-QT syndrome (LQTS) patients who continue to have
cardiac events (CEs) despite β-blockers is complex. We assessed the long-term efficacy of …

ContextIn long QT syndrome (LQTS), disease severity and response to therapy vary
according to the genetic loci. There exists a critical need to devise strategies to expedite …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited disease
characterized by adrenergically mediated polymorphic ventricular tachycardia leading to …

Background—Brugada syndrome (BrS) primarily associates with the loss of sodium channel
function. Previous studies showed features consistent with sodium current (I Na) deficit in …

Catecholaminergic polymorphic ventricular tachycardia (VT) is a lethal familial disease
characterized by bidirectional VT, polymorphic VT, and ventricular fibrillation …

Aims The shRNA-mediated loss of expression of the desmosomal protein plakophilin-2
leads to sodium current (INa) dysfunction. Whether pkp2 gene haploinsufficiency leads to …

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in
young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1. 5 …