Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

OBJECTIVE: To determine the pattern of accumulation of damage in an inception cohort of
patients with systemic lupus erythematosus (SLE) followed yearly for at least 15 years, and to …

Background Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis
of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes (‘psoriatic
disease’) that is defined by shared molecular pathogenesis resulting in excessive, prolonged …

The population of the province of Newfoundland and Labrador is genetically isolated. This
isolation is evidenced by an overabundance of several monogenic disorders. The …

Psoriasis and psoriatic arthritis (PsA) both have substantive genetic determinants. Numerous
candidate regions and genes have now been replicated in disease susceptibility, and to a …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …

Background Autoinflammatory diseases manifest inflammation without evidence of infection,
high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations …

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …

Background Many patients with psoriasis develop psoriatic arthritis, a chronic inflammatory
disease that afflicts peripheral synovial, axial, and entheseal structures. The fully human …