Listen and Learn!
Cellecta scientists and collaborators will present their work at the American Association of Cancer Research (AACR) Annual Meeting 2024.
I. Exhibitor Spotlight Theatre Event
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Refreshments will be provided. Space is limited.
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Applications of TCR & BCR Repertoire Profiling: Insights into the Adaptive Immune Response in T-cell Lymphomas and more
Spotlight Theatre B, Tuesday, April 9 2024, 3:00-4:00 p.m.
Exhibit Hall, San Diego Convention Center
Introductory Remarks: Paul Diehl, PhD, COO, Cellecta
Speaker 1: Alex Chenchik, PhD, President & Chief Scientific Officer, Cellecta
Title: TCR & BCR Repertoire Analysis and Other Approaches for the Discovery of Drug Targets, Resistance Mechanisms and Biomarkers
T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding disease mechanisms. We introduce a novel technology for profiling of all human TCR and BCR variable regions together with phenotypic characterization of immune cells in bulk in PBMCs and immune cell fractions. Preliminary data shows that TCR/BCR clonotype analysis combined with targeted expression profiling of immune cells can be applied for large-scale discovery in several immune-responsive model systems.
Speaker 2: Utpal Davé, MD, Associate Professor of Medicine, Associate Professor of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN.
Title: Dissecting the role of T-cell receptors in T-cell large granular lymphocytic leukemias
The etiology of T-LGL (T-cell large granular lymphocytic leukemias) and its accompanying autoimmune disease manifestations are mostly unknown. With the help of Cellecta’s sequencing technologies, we investigated the most abundant TCR clonotypes in a T-LGLL patient with severe neutropenia. Further analysis of the CDR3 region (VDJdb server) identified putative antigens recognized by the expanded clonotypes, allowing us to devise a model for the onset and development of T-LGL.
This Exhibitor Spotlight Theater is a promotional activity and is not approved for continuing education credit. The content of this Exhibitor Spotlight Theater and opinions expressed by presenters are those of the sponsor or presenter and are not of the American Association for Cancer Research® (AACR).
Evaluation of BCR spike-in controls using DriverMap adaptive immune receptor (AIR) profiling technology
Presenter: Khadija Ghias, Product Manager, Cellecta
Poster Section 14 – 27, Abstract Number 339 Sunday, April 7, 1:30 – 5:00 pm
Universal synthetic TCR/BCR spike-in controls to evaluate immune receptor profiling assay and next-generation sequencing performance
Presenter: Alex Chenchik, PhD, President & CSO, Cellecta
Poster Section 1 – 18, Abstract Number 3976 Tuesday, April 9, 9:00 am – 12:30 pm
Single-cell TCRα/β and TCRγ/δ immune receptor profiling and immunophenotyping using a 96-well plate sorted-cell approach
Presenter: Alex Chenchik, PhD, President & CSO, Cellecta
Poster Section 15 – 22, Abstract Number 5643 Tuesday, April 9, 1:30 – 5:00 pm
Targeted RNA-seq of dried blood microsamples for convenient RNA biomarker monitoring
Presenter: Les Kobzik, MD, Chief Medical Officer, Cellecta
Poster Section 14 – 24, Abstract Number 2949 Monday, April 8, 1:30 – 5:00 pm
A flexible and efficient approach for single-cell CRISPR perturbation screens combined with targeted RNA-seq expression analysis
Presenter: Kitt Paraiso, PhD, Bioinformatics Specialist, Cellecta
CRISPR/saCas9 and CRISPR/spCas9 systems for combinatorial genetic screens (CRISPR-KO, CRISPRa, CRISPRi)
Presenter: Paul Diehl, PhD, Chief Operating Officer, Cellecta
Stop by and chat with us at Booth 1110 or book a time to meet.
Contact us: info@cellecta.com, +1 (650) 938-3910
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