Article Text
Statistics from Altmetric.com
In clinical medicine, we seek to heal, and it is a long held tenet that a ‘response’ to treatment should be congruent between a strictly defined objective outcome and the physician's perception of improvement. As we advance in our understanding of the pathogenesis of lupus and molecularly targeted therapies are being studied, pivotal FDA trials are relying on two major indices to gauge response in extrarenal activity; the BILAG-based Composite Lupus Assessment (BICLA), and the Systemic Lupus Responder Index (SRI). Accordingly, it is timely that Thanou et al1 address the critical issue of whether these instruments are faithfully reflective of what the clinician ‘really thinks’. The authors point out that both instruments have shortcomings. BICLA requires …