Background stress factors (SF), anxiety-depressive spectrum disorders (ADSD) in patients with rheumatic disorders (RD) are related to stress vulnerability
Methods 110 patients (62 – SLE, 48 – PAPS), mostly women (85 (77,3%)), mean (M±SD) age 37,5±12,2 years, were consecutively enrolled in the study. ADSD were diagnosed in accordance with ICD-10. PSS-10 scale was used.
Results The majority of patients suffered ADSD (100 (90,9%)), that were mostly related to SF and developed earlier than RD in 48 (77.4%) SLE and 31 (63.3%) PAPS patients.
SF in childhood (0–11 years) (58 (93,5%) vs 33 (68,8%) p=0,001), first of all parental deprivation in 0–3 years (44 (70.9%) vs 17 (35,4%), p=0,0001) were found more often in SLE than PAPS patients.
SF in adolescence (11–16 years) were more commonly found among SLE but not PAPS patients (34 (54.8%) vs 17 (35,4%), p=0,03) with more often social maladjustment in SLE (15 (24,2%) vs (4 (8,33%), p=0,02).
SF during few months before the RD onset were experienced by 45 (72.6%) SLE, 31 (64.5%) PAPS patients. SLE patients also were significantly more likely to be exposed to multiple stress factors before RD than PAPS (29 (46.8%) vs 9 (18.8%), p=0.002).
As a result, SLE were more vulnerable to stress factors compared to PAPS patients, according to PSS-10: 28,7±6,25 vs 26,2±6,68, p=0,05.
Conclusions SF in childhood are related to social maladjustment and predispose to ADSD and SLE onset.
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