Abstract
Background Systemic lupus erythematosus is a chronic-systemic autoimmune disease that may affect different organ and organ system. Pathogenesis of SLE is not well understood but high inflammatory response of innate and adaptive immunity were thought to be main hallmark of the disease. IL-6 cytokines, which mainly secreted by Th-1 activation, were responsible to the pro-inflammatory response that affect inflammation and correlated with lupus disease activity. Meanwhile, IL-17 cytokines, secreted by Th-17 cells, also cytokines that believed to maintain the regulatory of immunity. This study is aimed to determining the correlation between serum of IL-6 with ratio of IL-6 and IL-17 cytokines on active SLE patients.
Methods SLE patients with active disease activity were recruited as subject of this study. Diagnosis criteria of SLE was using American College of Rheumatology (ACR) 1997 revised and MEX-SLEDAI was using to measured disease activity of lupus, which score >2 was considered as active disease activity. IL-6 and IL-7 was measured using ELISA methods and correlation of IL-6 and ratio of IL-6/IL-17 cytokines was performed using computerised statistical analysis program, with p<0,05 considered as significant correlation.
Results On this study, there were 50 SLE patients that included as subject of our study. Correlation analysis study was performed using computerised statistical analysis which we found that there was significant correlation between Il-6 cytokine serum with ratio of IL-6/IL-17 in SLE patients with p = < 0,05, r = 0,995
Conclusions There is significant correlation between cytokines of IL-6 and ratio of IL-6/IL-17 cytokines serum on active lupus patients. From this study, it’s important to determine the ratio of these inflammatory cytokines serum on blood peripheral to assess disease progression and response to the treatment, in addition to using existing disease activity instruments such as SLEDAI2K or MEX-SLEDAI.
