Description Due to oral bleeding, a 34-year-old male patient was admitted to the hospital. Additionally, he developed hematochezia as a result of an anal fissure brought on by a hard stool. In the months prior, he had experienced persistent diarrhoea and a biopsy during a colonoscopy revealed non-specific colitis treated afterwards with mesalazine. He also had a history of acute coronary syndrome. Hyperpigmented malar rash, and plaques in both ears, hands, and feet were notable physical findings. The findings of the laboratory tests showed proteinuria, microscopic hematuria, anaemia, thrombocytopenia, normal creatinine levels, and low albumin level. The participation of multiple systems casts doubt on SLE. Results from the ANA IF and ANA profile further support the diagnosis of SLE. The patient showed a good response to methylprednisolone given in the pulse dose. Despite the tapering of steroids, the patient has continued to improve after being given azathioprine and hydroxychloroquine.

Conclusions 1. The diagnosis of SLE should be entertained despite male gender in those presented with multi-systems involvement;

2. Unlike the majority of men with SLE, this male patient has responded favourably to treatment