Background Immune thrombocytopenia (ITP) is a common hematologic manifestation in systemic lupus erythematosus (SLE). Thrombocytopenia can persist for more than one year, which is defined as chronic thrombocytopenia. This study aimed to identify the clinical characteristics and risk factors for the chronic thrombocytopenia in SLE-ITP.
Methods We retrospectively reviewed patients who were diagnosed with SLE-ITP at a tertiary hospital between January 2000 and December 2021. The clinical and laboratory characteristics were analyzed according to the progression of chronic thrombocytopenia. Factors associated with chronic thrombocytopenia were evaluated by logistic regression analysis.
Results Of 121 SLE patients with ITP, 29 (24.0%) patients progressed to chronic thrombocytopenia lasting more than 1 year. The mean initial platelet count was lower in patients with chronic thrombocytopenia than those without (29.7 vs. 49.3 × 109/L, P < 0.001). Multivariable analysis showed that body mass index (BMI) (adjusted odds ratio [aOR] = 1.194, 95% confidence interval [CI] = 1.014–1.406), severe thrombocytopenia (< 20 ×109/L) (aOR = 3.974, 95% CI = 1.290–12.240), and recurrence of thrombocytopenia within 1 year (aOR=10.052, 95% CI=3.177–31.803) were significantly associated with the risk of chronic thrombocytopenia.
Conclusions Approximately one-quarter of the patients progressed to chronic thrombocytopenia in SLE. High BMI, severe thrombocytopenia, and recurrence of thrombocytopenia within 1 year were risk factors for the development of chronic thrombocytopenia in patients with SLE-ITP.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.