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Short Oral Presentation
Short oral presentation session 1: SLE etiology & pathogenesis 1
LSO-098 Decreased natural killer T-like cells correlated to disease activity in systemic lupus erythematosus
  1. Sumei Tang1,
  2. Yushu Wang2,
  3. Xiangbo Ma3,
  4. Xiaohong Xiang1,
  5. Xinhua Zhou4,
  6. Yan Li5,
  7. Yuan Jia1,
  8. Fanlei Hu1 and
  9. Yingni Li1
  1. 1Rheumatology and Immunology, Peking University People’s Hospital, China
  2. 2Inspection Center, Qingdao University Medical College Afliated Yantai Yuhuangding Hospital, China
  3. 3Department of Rheumatology and Immunology, Handan First Hospital, China
  4. 4Clinical Laboratory, Third Hospital of Nanchang, China
  5. 5Clinical Laboratory, First People’s Hospital of Jinzhong, China

Abstract

Background The NKT-like cells were known to play a role of the suppression in many chronic inflammatory diseases. This study was designed to investigate both of the expression and the possible role of NKT-like cells in SLE patients.

Methods 79 patients with SLE together with 30 age- and sex-matched healthy controls were enrolled. Flow cytometric determination of peripheral NKT-like cells was carried out for all participants by detecting the absolute counts (Abs) and percentage (%) of CD3+CD16+CD56+ cells. Disease activity index, laboratory parameters and clinical manifestations were collected. The correlation between the cells and these parameters were analyzed.

Results SLE patients had, with respect to controls, considerably decreased values of NKT-like cells (P < 0.001 in both absolute number and percentage). The absolute number of NKT-like cells were found to have positive correlations with WBC, RBC, PLT, C3, C4, IgM and negative correlations with the disease duration, SLEDAI-2K, anti-dsDNA, anti-nucleosome, anti-ribosomal protein, and CRP, ESR. Meanwhile, it was found that the percentage values of NKT-like cells decreased in SLE patients with nephritis which was correlated with anti-ribosomal protein and CRP in comparison to SLE patients without nephritis. Moreover, an increase in the NKT-like cell counts was also observed in the patients with a clinical response to the treatment.

Conclusions The absolute counts and frequencies of NKT-like cells decreased in SLE patients significantly, which correlated to disease activities and could recover to normal after the treatment. The NKT-like cells may play an important role in the pathogenesis of SLE and could be a useful marker in the disease assessment.

  • NKT-like cells
  • systemic lupus erythematosus
  • disease activity
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/lupus-2023-KCR.50

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