Article Text

Download PDFPDF

LSO-023 Clinical characteristics of SARS-CoV-2 infection in patients with systemic lupus erythematosus in Argentina: data from the SAR-COVID national registry
  1. Carolina Isnardi1,
  2. Karen Roberts1,
  3. Yohana Tissera2,
  4. Ingrid Petkovic2,
  5. Guillermo Berbotto2,
  6. Carla Gobbi2,
  7. Romina Tanten2,
  8. Karina Cogo2,
  9. Cecilia Asnal2,
  10. Andrea Baños2,
  11. Florencia Vivero2,
  12. Maria Marcela Schmid2,
  13. Ma Alicia Lazaro2,
  14. Noelia German2,
  15. Lorena Takashima2,
  16. Julia Scafati2,
  17. Marina Laura Werner2,
  18. Luciana Casalla2,
  19. Carla Matellan2,
  20. Diana Marcela Castrillon2,
  21. Florencia Rodriguez2,
  22. Sebastián Moyano2,
  23. Maria Luz Martin2,
  24. Vanesa Cosentino2,
  25. Natalia Herscovich2,
  26. Elda Rossella Tralice2,
  27. Tatiana Barbich2,
  28. Dora Lia Vasquez2,
  29. Emilio Buschiazzo2,
  30. Pablo Maid2,
  31. Ana Carolina Ledesma2,
  32. Victor Yohena2,
  33. Gimena Gomez1,
  34. Rosana Quintana1 and
  35. Guillermo J Pons-Estel1
  1. 1Research Unit, Argentine Society of Rheumatology, Argentina
  2. 2SAR-COVID Investigator, Argentine Society of Rheumatology, Argentina


Background Patients with systemic lupus erythematosus (SLE) present greater severity of SARS-CoV-2 infection compared to the general population. High disease activity and some immunosuppressants have been associated with worse outcomes. The aim of this study was to describe the characteristics of SARS-CoV-2 infection in patients with SLE in Argentina from the SAR-COVID registry and to establish factors associated with a worse outcome.

Methods Observational study. Patients diagnosed with SLE with confirmed SARS-CoV-2 infection (RT-PCR and/or positive serology) from the SAR-COVID registry were included. Data was collected from August 2020 to March 2022. The outcome of the infection was measured using the World Health Organization – ordinal scale (WHO-OS). Severe COVID-19 was defined as an WHO-OS value ≥5. Descriptive analysis, Student’s T test, Mann Whitney U, ANOVA, Chi2 and Fisher. Multiple logistic regression.

Results A total of 399 patients were included, 93% female, with a mean age of 40.9 years (SD 12.2), 39.6% had at least one comorbidity. At the time of infection, 54.9% were receiving glucocorticoids, 30.8% immunosuppressants, and 3.3% biological agents. SARS-CoV-2 infection was mild in most cases, while 4.6% had a severe course and/or died. The latter had comorbidities, used glucocorticoids and had antiphospholipid syndrome (APS) more frequently and higher disease activity at the time of infection. In the multivariate analysis, high blood pressure (OR 5.1, 95%CI 1.8–15.0), the diagnosis of APS (4.7, 95%CI 1.2–15.8), and the use of glucocorticoids (10 mg/day or more: OR 5.5, 95%CI 1.6–20.5) were associated with severe hospitalization and/or death from COVID-19 (WHO-EO≥5).

Conclusions In this cohort of SLE patients with confirmed SARS-CoV-2 infection, most had a symptomatic course, 22.1% were hospitalized, and 5% required mechanical ventilation. Mortality was close to 3%. The diagnosis of APS, having high blood pressure, and the use of glucocorticoids were significantly associated with severe COVID-19.

  • COVID-19
  • SARS-CoV-2 infection
  • systemic lupus erythematosus

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.