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LSO-032 Predictors of first hospitalizations due to disease activity and infections in systemic lupus erythematosus patients
  1. Rosana Quintana1,
  2. Romina Nieto1,
  3. Rosa Serrano Morales1,
  4. Manuel F Ugarte-Gil1,
  5. Guillermina B Harvey1,
  6. Daniel Wojdyla1,
  7. José A Gómez-Puerta1,
  8. Mercedes A García1,
  9. Luis J Catoggio1,
  10. Verónica Saurit1,
  11. Cristina Drenkard1,
  12. Nilzio Antonio Da Silva1,
  13. Fernando Cavalcanti1,
  14. Eduardo Borba1,
  15. Emilia Sato1,
  16. Oscar Neira1,
  17. Loreto Massardo1,
  18. Gloria Vásquez1,
  19. Luis Alonso Gonzalez1,
  20. Marlene Guibert-Toledano1,
  21. Luis Silveira1,
  22. Ignacio García de la Torre1,
  23. María Josefina Sauza del Pozo1,
  24. Rosa Chacon1,
  25. Graciela S Alarcón1,
  26. Ashley Orillion2,
  27. Urbano Sbarigia3,
  28. Federico Zazzetti4,
  29. Bernardo A Pons-Estel1 and
  30. Guillermo Pons-Estel1
  1. 1Rheumatology, GLADEL (Latin American Group for the Study of Lupus), Argentina
  2. 2Rheumatology, Janssen Research and Development, Horsham, Spring House, USA
  3. 3Rheumatology, Janssen Pharmaceutica NV, Beerse, Belgium
  4. 4Rheumatology, Janssen Pharmaceutical Companies of Johnson and Johnson, Horsham, USA


Background Systemic Lupus Erythematosus (SLE) patients experience frequent hospitalizations; lupus flares and infections have been shown to be the two most common causes. The aim of this study is to describe the main causes and predictors of first hospitalizations due to disease activity and infections in SLE patients.

Methods SLE patients from GLADEL, a multi-ethnic, multi-national Latin-American (LA) cohort were studied. The first hospitalization during these patients’ follow-up due to either infection and/or SLE disease activity was examined. Baseline sociodemographic, clinical, damage (SDI) and treatments were evaluated as possible predictors. First, descriptive analyses were performed. Predictors of infection or SLE disease activity associated hospitalization were identified using univariate and multivariate logistic.

Results A total of 1341 patients were included; 1201 (89.6%) were female. Their median interquartile range (IQR) age at diagnosis was 27 (20–37) years and their median IQR follow up time 27.5 (4.7–62.2) months; 456 (34.9%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) were hospitalized for disease activity, infections, or both, respectively, as depicted in graph 1. In the multivariable analysis, arthritis was associated with hospitalizations due to infection. Serositis, disease activity and damage were associated with hospitalizations due to disease activity. Older age, higher socioeconomic status and antimalarial use were found to be protective, as depicted in table 1.

Conclusions In this large LA lupus cohort, one third of the patients had at least one hospitalization; of them, three quarters were due to SLE disease activity. Our findings call attention for controlling disease activity and preventing damage using antimalarials early in the disease course disease to prevent the first hospitalization.

Abstract LSO-032 Figure 1

Reason for the first hospitalization

Abstract LSO-032 Table 1

Univariable and multivariable logistic regression analysis of predictors of hospitalization due to disease activity and infections in patients with SLE

  • Systemic lupus erythematosus
  • Real-world evidence

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