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Short Oral Presentation
Short oral presentation session 8: SLE biomarkers 2
LSO-045 Multiple molecular biomarkers that predict response to treatment in lupus nephritis
  1. Dae Jin Park1,
  2. Young-Bin Joo2,3,
  3. Eunwoo Nam3,
  4. Jiyoung Lee3,
  5. So-Young Bang2,3,
  6. Hye-Soon Lee2,3 and
  7. Sang-Cheol Bae2,3
  1. 1Rheumatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea
  2. 2Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Republic of Korea
  3. 3Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea

Abstract

Background Little has been known regarding the biomarker to predict the treatment response in lupus nephritis. This study aimed to identify potential biomarkers that predict treatment response in lupus nephritis (LN).

Methods In this prospective longitudinal study, 66 active LN patients were included and underwent renal biopsy at the time of enrollment. Patients were divided into two groups according to one-year response: 50 responders and 16 non-responders. Serum and urine samples were collected at 0, 12, 24, and 48 weeks after induction therapy. Twelve serum and urine biomarkers were measured by the multiplex immunofluorescence assay.

Results Urine (VDBP, MCP-1, IL-6, and IP-10) and serum (IP-10 and IL-23) levels of 12 biomarkers sampled one year after treatment differed significantly between responders and non-responders. Compared with the baseline, their levels in one year were significantly higher in non-responders than in responders. Urine VDBP was significantly correlated with proteinuria (rho=0.62, p< 0.0001), creatinine (rho=0.37, p=0.0025), and renal activity index (rho=0.35, p=0.0042).

The change in urine IL-6 and IL-23 levels during three months after induction treatment could predict the treatment response in lupus nephritis with an AUC of 0.70 (p=0.025) and 0.71 (p=0.018), respectively. A model incorporating these two predictors into complement C3 and C4, which are significant clinical factors for treatment response, showed increased predictive value with an AUC of 0.78.

Conclusions Urine VDBP, MCP-1, IL-6, IP-10, and serum IP-10 and IL-23 after one year of treatment differed significantly between responders and non-responders. Moreover, our predictive model composed of urine IL-6, 23, and complement showed increased discriminative ability between responders and non-responders in patients with LN.

  • lupus nephritis
  • biomarker
  • treatment response
http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

http://dx.doi.org/10.1136/lupus-2023-KCR.86

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