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LSO-053 Elevated expression of Hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus
  1. Ranran Yao,
  2. Liling Xu,
  3. Huaqun Zhu,
  4. Gong Cheng,
  5. Ziye Wang,
  6. Ruyu Liang,
  7. Wenwen Pei,
  8. Renge Liang,
  9. Yuan Jia,
  10. Hua Ye,
  11. Fanlei Hu and
  12. Yin Su
  1. Department of Rheumatology and Immunology, Peking University People’s Hospital, China


Background Accumulating evidence suggests that differentially expressed circular RNAs (circRNAs) play critical roles in immune cells of SLE patients. Hsa_circ_0000479 has been studied in the field of cancer and infection, whereas a few researches in autoimmune disease. The aim of this study was to discuss the roles and clinical value of hsa_circ_0000479 in SLE.

Methods Reverse-transcription real-time quantitative polymerase chain reaction (RT-qPCR) was conducted to detect the expressions level of hsa_circ_0000479 in PBMCs (HC: n = 8; SLE: n = 8) and in neutrophils (HC: n = 45; SLE: n = 80). The relationships between hsa_circ_0000479 levels in neutrophils and the clinical features and laboratory parameters in SLE were analyzed.

Results The expressions level of hsa_circ_0000479 in SLE patients were higher than that in healthy controls. Even the expressions of hsa_circ_0000479 of neutrophils were significant obvious than that of PBMCs of patients with SLE. Moreover, the expressions level of hsa_circ_0000479 on neutrophils in SLE patients were negatively related to absolute neutrophils count (r = -0.323, P = 0.004) and complement 3 (C3) (r = -0.346, P = 0.002), whereas positively correlated with anti-dsDNA (r = 0.394, P = 0.001) and anti-nucleosome antibodies (r = 0.384, P = 0.001). Additionally, the increased level of hsa_circ_0000479 was associated with several clinical manifestations, including mucocutaneous vasculitis involvement, anemia, arthritis, lupus nephritis, neuropsychiatric involvement, and pulmonary involvement of SLE.

Conclusions Hsa_circ_0000479 in neutrophils probable was one of factors which involved in the pathogenesis and had potential clinical value in SLE.

  • hsa_circ_0000479
  • Systemic Lupus Erythematous
  • Neutrophils

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