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LSO-086 Pregnancy outcomes in systemic lupus erythematosus: data from a multiethnic, multinational Latin American cohort
  1. Rosa M Serrano Morales1,
  2. Romina Nieto1,
  3. Rosana Quintana1,
  4. Paula Alba1,
  5. Sabrina Porta1,
  6. Lucia Hernandez1,
  7. Guillermo A Berbotto1,
  8. Verónica Bellomio1,
  9. Nilzio Antonio Da Silva1,
  10. Odirlei Andre Monticielo1,
  11. Fernando De Souza Cavalcanti1,
  12. Francinne Machado Ribeiro1,
  13. Eduardo F Borba1,
  14. Eloisa Bonfa1,
  15. Loreto Massardo1,
  16. Gustavo Aroca Martinez1,
  17. Andrés Cadena Bonfanti1,
  18. Gerardo Quintana López1,
  19. Mario Moreno1,
  20. Jorge A Esquivel Valerio1,
  21. María I Acosta1,
  22. Astrid Paats Nicora1,
  23. Claudia S Mora Trujillo1,
  24. Marina Scolnik1,
  25. Diana Fernandez1,
  26. Carmen Funes Soaje1,
  27. Verónica Saurit1,
  28. Mercedes García1,
  29. Eduardo Kerzberg1,
  30. Graciela Gómez1,
  31. Cecilia Pisoni1,
  32. Edgard Torres dos Reis Neto1,
  33. Iris Guerra Herrera1,
  34. Oscar Neira Quiroga1,
  35. Carlos A Cañas1,
  36. Miguel A Saavedra Salinas1,
  37. Margarita Portela Hernández1,
  38. Hilda Fragoso Loyo1,
  39. Luis H Silveira1,
  40. Ignacio García de la Torre1,
  41. Manuel Ugarte-Gil1,
  42. Armando Calvo-Quiroz1,
  43. Roberto Muñoz Louis1,
  44. Ricardo Robaina1,
  45. Vicente Juárez1,
  46. Álvaro Danza1,
  47. Carlos E Toro-Gutierrez1,
  48. Carlos Abud Mendoza1,
  49. Ana Malvar1,
  50. Graciela S Alarcón1,
  51. Ashley Orillion2,
  52. Urbano Sbarigia2,
  53. Federico Zazzetti2,
  54. Guillermo J Pons-Estel1 and
  55. Bernardo A Pons-Estel1
  1. 1Latin American Group for the Study of Lupus, GLADEL, Argentina
  2. 2Janssen Pharmaceutical Companies of Johnson and Johnson, ., USA


Background Obstetric morbidity (OM) is higher in Systemic Lupus Erythematosus (SLE) women than in healthy ones. Few data on SLE pregnancy outcomes in Latin America (LA) have been reported. The aim of this study was to assess SLE pregnancy outcomes in LA.

Methods GLADEL 2.0 is an observational prevalent/incident cohort started in 2019.1 To date, 43 centers from 10 LA countries have enrolled 1030 SLE patients, ≥18 years, 1982/1997 ACR or SLICC criteria. Women with at least one pregnancy were included. Past and ongoing (6, 12, 24 months follow-up) OM (miscarriages, fetal deaths, pre-eclampsia, prematurity, neonatal lupus) were evaluated.

Results At inclusion, 329 women have had at least one pregnancy [median (IQR): 2 (1–3)]: table 1. Of them, 293 (89.1%) had ≥1 live birth and 183 (55.6%) developed OM. Pre-eclampsia occurred in 49 (14.9%). Among 71 (21.6%) women with anti-SS-A(Ro)/SS-B(La) antibodies, 3 (4.2%) developed neonatal lupus (without cardiac involvement). Anti-phospholipid syndrome (APS) was associated with a higher risk of pregnancy complications (52.2% vs 10.0%; p< 0.001). Of the 755 pregnancies reported, 551 (73.0%) resulted in live births, of which 79 (14.3%) were premature. The remaining pregnancies ended in 178 (23.6%) miscarriages and 41 (5.4%) fetal deaths. During 2-follow-up years (figure 1), 24 single pregnancies occurred. All occurred under antimalarials; 16 (66.7%) resulted in live births, 4 (25.0%) premature; 12 (50.0%) developed OM. There were seven (29.2%) miscarriages and one fetal loss (4.2%) related to severe pre-eclampsia. One cholestasis gravidarum (4.2%) lead to prematurity. New cases of neonatal lupus were not reported.

Conclusions In GLADEL 2.0 cohort, around half of the women studied presented OM, being frequently related to APS. Miscarriages, prematurity, pre-eclampsia, and fetal deaths were the most common fetal-maternal complications. The incidence of neonatal lupus was lower than previously reported (16%).2

Abstract LSO-086 Figure 1

Pregnancy outcome during 2-year follow-up (6, 12 and 24 months

Abstract LSO-086 Table 1

Sociodemographic, clinical and treatment characteristics among SLE women with at least one pregnancy at cohort inclusion related to obstetric morbidity


  1. A longitudinal multiethnic study of biomarkers in systemic lupus erythematosus: Launching the GLADEL 2.0 Study Group. Gómez-Puerta JA, Pons-Estel GJ, Quintana R, Nieto R, Serrano Morales RM, Harvey GB, Wojdyla D, Scolnik M, Funes Soaje C, Alba Moreyra P, Novatti E, Arizpe F, Berbotto GA, González Lucero L, Porta S, Pérez N, Rodriguez AM, Appenzeller S, de Oliveira E Silva Montadon AC, Monticielo OA, Cavalcanti FS, Machado Ribeiro F, Borba EF, Torres Dos Reis-Neto E, Neira O, Chahuán JM, Mimica M, Aroca Martínez G, Tobón GJ, Vásquez G, Quintana-Lopez G, Moreno Alvarez MJ, Saavedra MÁ, Cristobal MP, Fragoso-Loyo H, Amezcua-Guerra LM, González-Bello YC, Abud-Mendoza C, Esquivel-Valerio JA, Duarte M, Acosta Colman I, Mora-Trujillo C, Reátegui-Sokolova C, Calvo Quiroz AA, Muñoz-Louis R, Cairoli E, Rosas I, Rebella M, Cardiel MH, García de la Torre I, Catoggio LJ, Alarcón GS, Pons-Estel BA. Lupus. 2021 Jan 28:961203320988586.

  2. Cimaz R, Spence DL, Hornberger L, Silverman ED. Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants born to mothers with anti-Ro autoantibodies. J Pediatr 2003;142:678–83.

  • Systemic Lupus Erythematosus
  • Pregnancy Outcomes
  • Antiphospholipid Syndrome

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