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LSO-094 Analysis of microbiota in patients with systemic lupus erythematosus
  1. Junko Nishio1,2,
  2. Hiroshi Sato1,
  3. Eri Watanabe1,
  4. Mai Kawazoe1,
  5. Risa Wakiya3,
  6. Soichi Yamada1,
  7. Sei Muraoka1,
  8. Shotaro Masuoka1,
  9. Tomoki Hayashi4,
  10. Satoshi Mizutani1,
  11. Zento Yamada1,
  12. Keiko Koshiba1,
  13. Izumi Irita1,
  14. Miwa Kanaji1,
  15. Karin Furukawa1,
  16. Nobuyuki Yajima4,
  17. Hiroaki Dobashi3,
  18. Wataru Hirose5 and
  19. Toshihiro Nanki1
  1. 1Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Japan
  2. 2Department of Immunopathology and Immunoregulation, Toho University School of Medicine, Japan
  3. 3Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Kagawa University, Japan
  4. 4Division of Rheumatology, Department of Medicine, Showa University, Japan
  5. 5Department of Rheumatology, Hirose Clinic of Rheumatology, Japan


Background Previous studies have reported that gut dysbiosis is observed in systemic lupus erythematosus (SLE) and linked to the diseases. However, the relation with the pathogenesis remains unclear. We explored gut microbiota in patients with SLE and investigated the association with the onset and activity of disease and clinical findings

Methods Stool samples were collected from 25 patients with new-onset SLE (noSLE), 30 patients with SLE in remission (remSLE) and 30 healthy controls (HC). Stool samples from 23 patients with noSLE were collected at 3, 6 and 12 months after the treatment started. Microbial composition was determined by bacterial 16S rRNA analysis to examine α- and β- diversities and abundances of phylum, family, genus and species.

Results Patients with noSLE displayed altered α -diversity, decreases in butyrate-producing bacteria including Eubacterium rectale, Lachnospira pectinoshiza, Anaerostipes hadrus, Fusicatenibacter saccharivorans, and Anaerobutyricum halli, and increases in Hungatella efuluvii, Intestinibacter barrtletti, and Eisenbergiella tayi. Some had correlation with SLEDAI, while the others did not. Furthermore, the abundance of specific bacterial species was correlated with involved organs and the positivity of autoantibodies.

Conclusions Butyrate plays a role in the homeostasis of gut and regulation of immune cells, and therefore a decrease in butyrate-producing bacteria may be involved in the pathogenesis of the disease. Our study suggests that the gut microbiota possibly contributes to the activity and clinical findings of SLE.

  • SLE
  • microbiota
  • butyrate

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