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Poster Presentations
P97 LNMap: a curated computational resource of molecular pathways in lupus nephritis
  1. George Sentis1,
  2. Chrysa Rapti1,
  3. Maria Grigoriou1,2,
  4. Eirini Maria Stergioti1,
  5. Eleftherios Chavatzas1,
  6. Panagiotis Garantziotis3,4,
  7. Aggelos Banos1,
  8. Marek Ostaszewski5.6,
  9. Dimitrios T Boumpas1,2 and
  10. Anastasia Filia1
  1. 1Laboratory of Autoimmunity and Inflammation, Center of Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece
  2. 24
  3. th Dept. of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece
  4. 3School of Medicine, National and Kapodistrian University of Athens, Athens Greece
  5. 4Dept. of Internal Medicine 3-Rheumatology and Immunology, Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany
  6. 5Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg
  7. 6ELIXIR Luxembourg, Esch-sur-Alzette, Luxembourg

Abstract

Objective The generation of an open-access interactive lupus nephritis disease map (LNMap). The map will be a reference resource depicting the complex molecular pathways underlying LN pathogenesis and the key regulators of the disease. This graphical and computational repository will integrate existing knowledge, identify gaps and provide a scaffold for reproducible molecular signaling models of LN.

Methods Major review papers were used to identify the most important cell types and pathways associated with LN. Manual literature search focusing on the selected cell types was performed to detect inter- and intracellular interactions associated with LN. Molecular interactions between and within these cell types that have been associated with LN undergo manual literature curation. These interactions are depicted utilizing CellDesigner software and Systems Biology Graphical Notation and annotated using Minimum Information Required In the Annotation of Models (MIRIAM). Identified gaps in knowledge will be completed by data-driven, automated mining of literature and interaction databases.

Results LNMap will be comprised of molecular interactions between and within neutrophils, macrophages, mesangial cells, CD4+ T-cells, CD8+ T-cells, dendritic cells, monocytes, podocytes and B-cells. The map currently is comprised of a kidney compartment that contains sub-compartments for each selected cell type (figure 1A). At this stage, 164 publications are present in the database of the LNmap, focusing on dendritic (N=30) and mesangial (N=64) cells (figures 1B, C), CD4+ T cells (N=31), podocytes (N=16), neutrophils (N=11), macrophages (N=1), monocytes (N=4) and B cells (N=11).

Conclusions The LNmap, an ongoing dynamic project, will provide a useful resource of known pathways associated with the disease and will pinpoint gaps in our knowledge. The LNmap already constitutes a resource of molecular interactions with a multifaceted value aiming to assist anyone interested in the molecular landscape of LN. Future efforts are designed for the map to reach its end-users through the MINERVA Platform.

Abstract P97 Figure 1
Abstract P97 Figure 1

(A) The Lupus nephritis Map. (B) Interactions between dendritic cells, mesangial cells and B cells. (C) Mesangial cell interactions

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ .

https://doi.org/10.1136/lupus-2024-el.151

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