Article Text

Download PDFPDF

ECG non-specific ST-T and QTc abnormalities in patients with systemic lupus erythematosus compared with rheumatoid arthritis
  1. Laura Geraldino-Pardilla1,
  2. Yevgeniya Gartshteyn1,
  3. Paloma Piña2,
  4. Marina Cerrone3,
  5. Jon T Giles1,
  6. Afshin Zartoshti1,
  7. Joan M Bathon1 and
  8. Anca D Askanase1
  1. 1Columbia University, College of Physicians & Surgeons, New York, New York, USA
  2. 2Northwestern University, Chicago, Illinois, USA
  3. 3New York University (NYU) School of Medicine, New York, New York, USA
  1. Correspondence to
    Dr Laura Geraldino-Pardilla; Lbg2124{at}


Objectives Cardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Although only explored in one study, ECG non-specific ST-T abnormalities, in addition to corrected QT-interval (QTc) prolongation, were recently reported in an SLE inception cohort. Importantly, these ECG abnormalities are known predictors of CVD mortality in the general population, yet their prevalence in patients with established SLE has not been evaluated.

Methods We cross-sectionally investigated the presence of non-specific ST-T and QTc abnormalities in 50 patients with SLE, predominantly Hispanic and black, without CVD or SLE-related cardiac involvement and compared them with 139 patients with RA without CVD. Demographics, disease-specific characteristics and CVD risk factors were ascertained and adjusted for.

Results Patients with SLE (mean age 36±13 years, 92% women, 6 years median disease duration, 96% Hispanics and blacks) had a 3.3-fold higher adjusted prevalence of non-specific ST-T abnormalities (56% vs 17%; p <0.0001) compared with RA, despite the older age and higher percentage of men in the RA group. The QTc was 26 ms longer in SLE compared with RA (p=0.002) in the setting of a higher percentage of women, blacks, Hispanics and higher C reactive protein levels in the SLE group.

Conclusions This study demonstrates a high prevalence of ECG abnormalities in predominantly Hispanic and black patients with SLE. Longitudinal evaluation of the progression to potentially life-threatening arrhythmias and/or cardiovascular events is warranted.

  • Cardiovascular Disease
  • Systemic Lupus Erythematosus
  • Autoimmune Diseases

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors All authors participated in the design of the study, collection of data, analysis and final approval of the manuscript.

  • Funding Supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grants AR-050026 (JMB).

  • Competing interests None declared.

  • Ethics approval Columbia University and Johns Hopkins Medical institution review boards.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.