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Dynamics of pulse wave velocity and vascular augmentation index in association with endothelial progenitor cells in SLE
  1. Peter Korsten1,
  2. Daniel Patschan1,
  3. Elvira Henze1,
  4. Timothy B Niewold2,
  5. Gerhard Anton Müller1 and
  6. Susann Patschan1
  1. 1Department of Nephrology and Rheumatology, University Medicine Göttingen, Göttingen, Germany
  2. 2Department of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Professor Daniel Patschan; d.patschan{at}gmail.com

Abstract

Patients with SLE display a significantly higher cardiovascular risk (CVR). Pulse wave velocity (PWV) has meanwhile been established as a reliable parameter of end-organ damage. Endothelial progenitor cells (EPCs) are critically involved in vascular repair under both physiological and pathological conditions. The aim of the study was to analyse PWV and the Vascular Augmentation Index (VAI) and EPC numbers/regeneration in a well-defined German SLE cohort. Thirty patients were included. Only two individuals displayed a PWV of above 10 m/s. There was no correlation between PWV percentiles and disease activity as reflected by the SLE Disease Activity Index. Neither EPC colonies nor percentages of circulating EPCs (CD133+/KDR+) correlated with PWV/VAI in a positive or negative manner. Thus, it can be questioned whether pulse wave analysis and/or EPC proliferation and circulating cell numbers are truly useful for CVR assessment in SLE.

  • pulse wave velocity
  • cardiovascular risk
  • endothelial progenitor cells

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/lupus-2016-000185

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    Footnotes

    • Contributors PK wrote the manuscript, DP assisted in manuscript writing and analysed data, EH performed EPC analyses, TBN corrected the manuscript, GAM supplied financial support and SP designed the study and recruited all patients.

    • Funding This work was supported by the Heidenreich von Siebold Programm.

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval The study was approved by the local ethics committee of the Georg August-University Göttingen. All participants signed written consent.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement All data are presented in the manuscript.