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Poster Session
Genetics, epigenetics, omics, biomarkers and personalised medicine in SLE and autoimmunity
281 The clinical analysis of the characteristics of lupus mesenteric vasculitis (lmv) compared with lupus nephritis
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  1. J Chen1,
  2. R Wan2,
  3. X Rong3,
  4. R Wang3 and
  5. X Huang4
  1. 1Xiang Ya Second Hospital, Department of Rheumatology, chang sha, China
  2. 2West China school of medicine- Sichuan University-, Department of Rheumatology, Si Chuan, China
  3. 3West China Hospital- Sichuan University, Department of Rhematology, Si Chuan, China
  4. 4Xiang Ya Second Hospital, Rheumatology, chang sha, China

Abstract

Background and aims Evaluate the clinical characteristics of lupus mesenteric vasculitis (LMV) in a large cohort.

Methods The in-patients with Systemic Lupus erythematosus (SLE) admitted to the West China Hospital from 2009 to 2015 were analysed. Diagnosis of LMV was made according to the clinical symptoms, abdominal image and the reaction to steroids. The patients with Lupus Nephritis (LN) were set as the control. Qualitative differences were analysed using the chi-square test.

Results Among 3143 patients with SLE, 103 patients were diagnosed as LMV with the incidence of LMV being 32.8%. Among those patients with LMV, 96.1% was female and the average age was 35.8 years old, 37 (35.9%) patients were diagnosed as SLE with LMV as the one of onset symptoms, 54 (52.4%) patients were misdiagnosed at the first time. The incidence of abdominal pain was 87.4%, while that of pelvic effusion 68.04%, vomiting 70.9%, bloating 68.6% and diarrhoea 67.0%. Their average score of the SLE disease activity index (SLEDAI ) (including LMV as vasculitis ) was 21.8±7.7. During the following-up for 2–96 months, partial remission of the incidence of abdominal pain within a week was 87.9%, and 98.8% of the LMV patients got complete remission in a month. Eight cases experienced disease relapse (8.0%). Rash (X2=6.7255, p=0.0095), high creatinine (X2=6.746,p<0.0001) , hypercholesterolemia (X2=21.2986, p<0.0001), leukopenia (X2=7.4153, p=0.0245) were presented more often in the patients with LMV than in LN.

Conclusions There were differences between LMV and LN in clinical symptoms and laboratory findings. A much lower mortality rate was found in LMV.

https://doi.org/10.1136/lupus-2017-000215.281

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