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296 Case series involving obstetrics experiences and outcomes in connective tissue disease patient in universiti kebangsaan malaysia medical centre (ukmmc): a single centre experience
  1. MS Mohamed Said,
  2. JB Eeu,
  3. AS Mohamed Yazid,
  4. A Chandra,
  5. FN Ahmad Yazid,
  6. N Abd Aziz,
  7. SS Shaharir and
  8. KT Chew
  1. Universiti Kebangsaan Malaysia Medical Centre, Medical, Kuala Lumpur, Malaysia


Background and aims Connective tissue diseases (CTD) such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), antiphospholipid syndrome (APS) and others are likely to be worsening during pregnancy. There are poor pregnancy performances because of the abnormal immune system activity. The aim of the study was to observe the obstetrics experiences and the outcomes.

Methods A retrospective study was done and a total of 58 cases of pregnancy were taken from year 2010–2015 in Universiti Kebangsaan Malaysia Medical Centre (UKMMC).

Results Fifty-eight pregnancies were observed in 44 women where there were fifty pregnancies (86.2%) with SLE, 4 (6.9%) pregnancies with RA and 4 (6.9%) pregnancies with APS. There were 6 (10.3%) pregnancies in active group and 52 (89.7%) pregnancies in remission group. Among the 58 pregnancies, there were 29 (50.9%) birth with no complication, 9 (15.5%) miscarriages, 8 (13.8%) premature babies, 2 (3.4%) stillbirth, 1 (1.7%) intrauterine growth restriction, 1 (1.7%) neonatal death and 7 (12.1%) others (pre-eclampsia, impending eclampsia, oligohydramnios, chorioamnionitis, persistent urinary tract infection, fetal distress and placenta previa). Rate of live birth is affected by type of CTD (x2=6.520, p=0.038) and anti double stranded DNA (x2=6.157, p=0.021). Pregnancy has a significant association with Complement 3 (C3) value (t=2.003, p=0.05).

Conclusions This study showed there is a significant relationship between antidsDNA and type of CTD with pregnancy. C3 value also showed significant changes in pre pregnancy and during pregnancy.

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