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Poster Session
Genetics, epigenetics, omics, biomarkers and personalised medicine in SLE and autoimmunity
331 Il-1Β and il-6 are highly expressed in rf+ige+ systemic lupus erythematous subtype
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  1. Y Wu1,
  2. B Cai1,
  3. J Zhang1,
  4. B Shen1,
  5. Z Huang1,
  6. C Tan2,
  7. CC Baan3 and
  8. L Wang1
  1. 1West China Hospital affiliated Sichuan University, Department of Laboratory Medicine, Chengdu, China
  2. 2West China Hospital affiliated Sichuan University, Department of Rheumatology, Chengdu, China
  3. 3West China Hospital affiliated Sichuan University, Department of Laboratory Medicine, Rotterdam, Netherlands Antilles

Abstract

Background and aims Systemic lupus erythematous (SLE) is anautoimmune disease with great heterogeneity in pathogenesis and clinical symptoms. To better categorise SLE subtypes we determined the dominant cytokines based on RF+IgE+ (both RF and IgE were positive ) familial SLE.

Methods RF, IgE and multiple cytokines (i.e., IL-1β, IL-6, IL-8, IL-10, IL-17, IFN–γ, IP-10, MCP-1 andMIP-1β) were measured in sera of familial SLE (n=3),non-inherited SLE (n=108) and healthy controls (n=80).

Results Three SLE patients in family and 5 out of 108 non-inherited patients featured with RF+IgE+. These RF+IgE+SLE patients expressed significantly higher levels of IL-1β and IL-6 than the other SLE patients (p<0.05). IL-6 correlated with both IgE and IL-1β levels in RF+IgE+ SLE patients(r2=0.583,p=0.027; r2=0.847,p=0.001).

Conclusions Both IL-1β and IL-6 are highly expressed cytokines in RF+IgE+ SLE subtype which may be related to the pathogenesis of this special SLE subtype.

https://doi.org/10.1136/lupus-2017-000215.331

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