Background and aims Interferon lambda (IFN-λ) is a novel type of interferon produced by dendritic cells (DC). Despite its binding to a different receptor, IFN-λ shares functional similarities with type I IFN (IFN-I) by upregulating the expression of IFN-stimulated genes. The role of IFN-λ in DC biology and in autoimmunity remains unknown.
to identify the DC subsets producing IFN-λ.
to investigate the role of IFN-λ in DC functions.
to investigate the role of IFN-λ in SLE.
Mouse and human DC subsets were stimulated ex vivo and the IFN-λ expression was measured.
The maturation and the capacity of DC to cross-prime T cells was compared in WT and IFN-λR-/- mice. T cell cross-priming by human DCs was measured ex vivo in the presence of exogenous IFN-λ.
Serum levels of IFN-λ was measured in lupus-prone mice and in SLE patients. The phenotype of the blood DC subsets from SLE patients was also characterised.
Mouse plasmacytoid DC (pDC) and CD8+ DC highly secrete IFN-λ. In humans, the CD141+ DC are the major IFN-λ producers.
IFN-λ enhances the capacities of mouse and human DCs to maturate and to cross-prime T cells.
High serum levels of IFN-λ were detected in lupus-prone mice and in some SLE patients. SLE patients display increased activation of the IFN-producing DC subsets: the pDCs (producing IFN-I) and the CD141+ DCs (producing IFN-λ).
Conclusions IFN-λ is produced by some DC subsets and enhances their functions. Furthermore, IFN-λ is expressed during SLE, suggesting a potential role of the cytokine in the aetiology of SLE.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.