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33 Association of the lupus low disease activity state (lldas) with health related quality of life
  1. V Golder1,
  2. R Kandane-rathnayake1,
  3. A Hoi1,
  4. M Huq2,
  5. W Louthrenoo3,
  6. Y An4,
  7. ZG Li4,
  8. SF Luo4,
  9. S Sockalingam5,6,
  10. CS Lau7,
  11. MY Mok7,8,
  12. A Lateef7,8,
  13. S Navarra9,
  14. YJ Wu5,
  15. L Hamijoyo10,
  16. M Chan11,
  17. S O’Neill12,
  18. F Goldblatt13,
  19. M Nikpour2 and
  20. E Morand1
  1. 1School of Clinical Sciences at Monash Health, Rheumatology, Clayton, Australia
  2. 2Melbourne University, Rheumatology, Fitzroy, Australia
  3. 3Chiang Mai University Hospital, Rheumatology, Chiang Mai, Thailand
  4. 4People’s Hospital- Peking University Health Sciences Centre, Rheumatology, Beijing, China
  5. 5Chang Gung Memorial Hospital, Rheumatology, Guishan Township, Taiwan R.O.C
  6. 6University of Malaya, Rheumatology, Kuala Lumpur, Malaysia
  7. 7Hong Kong University, Rheumatology, Hong Kong, Hong Kong S.A.R
  8. 8National University Hospital, Rheumatology, Singapore, Singapore
  9. 9University of Santo Tomas Hospital, Rheumatology, Manila, Philippines
  10. 10University of Padjadjaran, Rheumatology, Bandung, Indonesia
  11. 11Tan Tock Seng Hospital, Rheumatology, Singapore, Singapore
  12. 12South Western Sydney Clinical School, Rheumatology, Liverpool, Australia
  13. 13Royal Adelaide Hospital, Rheumatology, Adelaide, Australia


Background and Aims Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). The Lupus Low Disease Activity State (LLDAS) definition has not been previously evaluated for association with patient reported outcomes. The objective of this study was to determine whether LLDAS was associated with better HR-QoL, and examine predictors of HR-QoL, in a large multiethnic, multinational cohort of SLE patients.

Methods HR-QoL was measured using the Medical Outcomes Study 36-item Short Form Health Survey (SF-36v2) in a prospective study of 1422 patients. Disease status was measured using SLE disease activity index (SLEDAI-2K), physician global assessment (PGA) and LLDAS.

Results Significant differences in SF-36 domain scores were found between patients stratified by ethnic group, education level, damage score, and with the presence of active musculoskeletal or cutaneous manifestations. In multiple linear regression analysis, Asian ethnicity (p<0.001), a higher level of education (p<0.001), younger age (p<0.001) and shorter disease duration (p<0.01) remained significantly associated with better physical component scores (PCS). Musculoskeletal disease activity (p<0.001) was negatively associated with PCS, and cutaneous activity (p=0.04) was negatively associated with mental component scores (MCS). Patients in LLDAS had better PCS (p<0.001) and MCS (p<0.001) scores and significantly better scores in multiple individual SF-36 domain scores. Disease damage was associated with worse PCS (p<0.001), but not MCS scores.

Conclusions Ethnicity, education, disease damage, and specific organ involvement impacts on HR-QoL in SLE. Attainment of LLDAS is associated with better HR-QoL.

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