Article Text

Download PDFPDF

373 Association between disease activity, quality of life and quality of sleep in patients with systemic lupus erythematosus (sle)
  1. D Monova1 and
  2. S Monov2
  1. 1Medical University – Sofia- Medical Institute, Department of Internal Diseases, Sofia, Bulgaria
  2. 2Medical University – Sofia, Department of Internal Diseases- Clinic of Rheumatology, Sofia, Bulgaria


Background and aims The aim of this study was to examine the association of SLE disease activity, quality of life and quality of sleep in patients diagnosed with SLE.

Methods 132 SLE patients with a confirmed diagnosis of SLE, according ACR classification criteria, were enrolled in this study. The patients completed the following questionnaires: the Pittsburg Sleep Quality Index (PSQI), the 12 item Short Form Health survey (SF-12), the Lupus Patient-Reported Outcome tool (PupusPRO), SLE Quality of Life Questionnaire (L-QoL). Clinical information, including the SLE Disease Activity Index (SLEDAI), was obtained from medical records. Student’s t-test, ANOVA, Pearson correlation measured were used in statistical analysis.

Results The majority of the participants (84,4%) had sleep disturbances (PSQI >5). Total PSQI score was weakly associated with all of the SF-12 subcategories and showed weak to moderate associations with LupusPRO subcategories (r<0,05), except for medication (r<0,2). “Sleep efficiency” was weakly associated with “physical health”, “physical function”, and “paim” in the SF-12 and LupusPRO. “Sleep quality” and “sleep disturbances” were weakly associated with “pain” and the “emotional” and “mental” subcategories in the SF-12 and LupusPRO. SLE QoL was significantly higher in patients with good sleep.

Conclusions We found that quality of sleep, especially “sleep efficiency”, was poor for the majority of patients with SLE. Quality of sleep was associated with various aspects of quality of life, especially pain, vitality, and emotional health. Management of pain and emotional health may be important for improving quality of sleep in SLE patients.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.