Background and aims Patients with autoimmune patients have to deal with their chronic disease, and it affects their quality of life. This study was aimed to compare the quality of life (QOL) of patient with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc).

Methods This study was cross sectional study, done in rheumatology outpatient clinic Hasan Sadikin Hospital Bandung, Indonesia in 2015–2016. It was conducted by asking patients diagnosed of SLE and SSc to fill the SF-36 form. Baseline characteristic, including age, gender, and duration of disease, were collected during the visit. The Mann-Whitney U test was used to analyse the comparison.

Results One hundred seventy patients were involved into this study, consisted of 127 SLE patients and 43 SSc patients, mostly female 162 patients (96.3%). Median of age was 34 (19 to 62) year and 40 (16 to 69) year (min-max), and duration of disease was 72 (3–252) and 36 (1–228) months (min-max), consecutively for SLE and SSc

All sections of quality of life in patient with SLE was significantly higher than patients with SSc with p<0.001, with exception on mental component score (MCS) was not significantly different in SLE compared to SSc (p=0.062).

Conclusions The quality of life of SLE patients is significantly higher than patients with SSc, except mental component score was not significantly different.