Article Text

Download PDFPDF

92 Effect of curcumin and vitamin d on disease activity, fatigue, and cytokine profile in systemic lupus erythematosus patients with deficiency vitamin d
  1. CS Wahono,
  2. H Kalim,
  3. I Saveria,
  4. CD Setyorini,
  5. Z Wahyuni,
  6. RA Dimpudus and
  7. H Kusworini
  1. Medical Faculty Brawijaya University, Rheumato-Immunology, Malang, Indonesia


Background and aims SLE patient who had deficiency of vitamin D, had worsen clinical manifestation. Vitamin D and Curcumin ; a novel Vitamin D Receptor (VDR) ligand, are immunomodulator. The purpose of this study, to compare efficacy whether curcumin supplementation in vitamin D treatment will give improvement of disease activity, fatigue and proteinuria in SLE patient with vitamin D deficiency.

Methods This study was a double blind RCT included 40 active SLE patient more than 18 yo with level 25(OH)D3 ≤30 ng/ml were enrolled for this study. There were divided into 2 group, control group who received cholecalciferol 3 × 400 IU plus placebo and trial group who received cholecalciferol 3 × 400 IU and curcumin 3 × 20 mg for 6 months. Demorgrafic data, family history, medications, laboratory test, SLEDAI and FSS were taken before and after treatment. Serum cytokines were measure uisng ELISA. The results between 2 groups were evaluated with independent t-test and spearman/pearson correlation test using SPSS software.

Results Age of participant are 28.1±8.1, disease duration 3.1±2.3 year.The addition of curcumin in the suplemtation treatment with vitamin D increase the benefit of vitamin D. Combination of curcumin and vitamin D result in better disease activity suppression , less fatigue and less proteinuria compare with vitamin D supplementation alone. The clinical improvement were related to decrease in proinflammatory cytokines ( IFNg, TNFa and IL-17 ). There were no major adverse events in both groups.

Conclusions The addition of curcumin to the vitamin D supplementation therapy result in better efficacy.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.