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PS9:172 Characteristics of lupus nephritis in saudi lupus patients: a retrospective observational study
  1. I Al-Homood,
  2. A Almasmaly and
  3. M Albirdisi
  1. King Fahad Medical City, Medical Specialities Department, Rheumatology Section, Riyadh, Saudi Arabia


Objective The aim of this study is to evaluate the prevalence, clinical, laboratory and histological types of lupus nephritis (LN) among Saudi patients.

Methods This is a retrospective study that done at King Fahad Medical City, Riyadh, Saudi Arabia, where clinical and laboratory data collected for a period from 2011–2016. All patients fulfilled the Systemic Lupus International Collaborating Clinics classification criteria (SLICC).

Results Out of 112 patients, 103 (92.0%) females, 9 (8.0%) males, mean age 34 (33.87±10.42) years. The mean of initial proteinuria level was 0.72 gm (0.72±1.34) and the mean serum creatinine 34.00 (82.33±83.88). The most common clinical characteristics were skin rash 70% and photosensitivity 61%.

With regards to comorbidities; Hypertension was found in 31 (27.7%), Hyperlipidemia in 16 (14.3%) and Diabetes mellitus in 12 (10.7%) of SLE patients.

Laboratory investigations revealed 67.0% had a positive ANA, 60.7% positive Anti DsDNA, 27.7% positive aPL, 17.9% positive Anticardiolipin igG, 18.8% positive Anticardiolipin IgM, and B2glycoprotein IgG was positive in 8.9% of patients.

44 (39.8%) out of 112 patients had a kidney biopsy and the histological types were as follow; Focal segmental glomerulosclerosis (FSGS) 2.2%, class I 2.2%, class II 6.8%, class III 27.2%, class IV 43.1%, V 6.8%, minimal change disease (MCD) 2.2%, Thrombotic Microangiopathy (TMA) 2.2%, non-specific 2.2% Normal 2.2%, poor biopsy 2.2%.


  • The most notable clinical manifestations were skin rash 70% followed by photosensitivity 61% and arthralgia 39%.

  • Patients with Hypertension, hyperlipidemia and diabetes mellitus had a higher risk of developing LN at any stage by 10%–28%.

  • The commonest class of lupus nephritis among our patients as proven by kidney biopsy is class IV 43.1% followed by class III 27.2%.

  • Lupus
  • Nephritis
  • Saudi

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