Systemic lupus erythematosus is a standard autoimmune disease, characterised by the production of antibodies against cellular core. The use of corticosteroids is effective in various manifestations of lupus. We will present a 45-year-old woman suffering from the disease for 5 years and received hydroxychloroquine, prednisolone and azathioprine. The patient received bisphosphonates and after three years had an automatic right-sided fracture of pubic bone. The patient was put up in denosumab and after one year she showed a 5th metatarsal fracture left. Computed Tomography of chest and upper abdomen were performed, where it was found an adrenal adenoma. Cortisol levels in the blood were elevated.After surgery it was found that adenoma produced cortisol. Since then, there wasn’t another automatic fracture.
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