Abstract
Introduction Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations and serologic markers. In this study, we analysed nine polyamine profiles of plasma from patients with SLE and healthy controls, and the relationship between the polyamine profiles and disease activity.
Methods The alterations of the polyamine metabolome in the plasma of 44 patients with SLE and fever were investigated using gas chromatography mass spectrometry in selected ion monitoring mode using N-ethoxycarbonyl/N-pentafluoropropionyl derivatives, and compared with those of 43 healthy controls.
Results Patients with SLE and healthy controls showed differences in five of nine polyamine metabolome profiles. Among five polyamines changed levels, four polyamines, namely N1-acetylcadaverine, spermidine, N1-acetylspermidine, and spermine, were dramatically decreased. However, the level of cadaverine was increased in patients with SLE. In the partial correlation with polyamine profiles and disease activity markers of SLE, several disease activity markers and nutritional markers were correlated with cadaverine, spermidine, and N8-acetylspermidine.
Conclusion Thus, our results provide a comprehensive understanding of relationship between that polyamine metabolomes and disease activity markers in patients with SLE and fever.
