Abstract
Purpose Renal involvement is one of the major determinants of outcome in patients with Systemic Lupus Erythematosus (SLE). Dyslipidaemia occurs frequently in Juvenile SLE. This study aimed to determine if there were differences in lipid profile in Juvenile SLE patients with lupus nephritis (LN) in two time points, time 1 at LN diagnosis and time 2 after 6–12 months of treatment.
Methods Retrospective analysis of the lipid profile of a population of Juvenile SLE patients with LN in two time points. Lipid profile evaluation included total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL) and low-density lipoprotein (LDL). Statistical analysis was performed using T Student Test. Significance level was set as <0.05.
Results At LN diagnosis, time 1, the mean TC was 198,1 mg/dL (±62,9), TG was 175,1 mg/dL (±89,5), HDL was 44,3 mg/dL (±16,9) and LDL was 120,6 mg (±61,2). At time 2, the mean TC was 188,2 mg/dL (±47.0), TG was 126,3 mg/dL (±57.1), HDL was 52,3 mg/dL (±13,8) and LDL was 115,9 mg/dL (±30,6).). Despite higher levels of TC, TG and LDL levels at time one, the variation of lipid profile between the two time points did not reach statistical significance.
Conclusions Our study showed that the lipid profile of LN patients tends to improve with LN treatment, as showed by the lower levels of TC, TG and LDL and higher levels of HDL observed at time 2.
