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PS3:62 Is there a relationship between vitamin d and complement in patients with juvenile systemic lupus erythematosus?
  1. M Guerra1,
  2. A Águeda2,
  3. I Jorge3,
  4. R Ferreira4,5,
  5. M Rodrigues5,6 and
  6. I Brito5,6
  1. 1Centro Hospitalar Vila Nova de Gaia/Espinho, Department of Rheumatology, Vila Nova de Gaia, Portugal
  2. 2Centro Hospitalar do Baixo Vouga, Department of Rheumatology, Aveiro, Portugal
  3. 3Centro Hospitalar do Porto, Department of Physical Medicine and Rehabilitation Department, Porto, Portugal
  4. 4Centro Hospitalar de São João, Department of Rheumatology, Porto, Portugal
  5. 5Faculty of Medicine of Porto University, Porto, Portugal
  6. 6Centro Hospitalar de São João, Paediatric Rheumatology Unit, Porto, Portugal


Purpose Complement consumption is a feature of active Systemic Lupus Erythematosus (SLE), and serum complement components measurement is used in clinical practice in the surveillance of these patients. Also, vitamin D deficiency is a common finding in SLE. This study aimed to evaluate the correlation between serum levels of 25-hydroxyvitamin D (25OH-D) and C3c/C4 in patients with juvenile SLE.

Methods A population of juvenile SLE patients was retrospectively evaluated. Data on demographic and clinical characteristics was collected. Serum 25-OH-colecalciferol (normal >30 ng/ml), C3c (normal >75 mg/dl) and C4 (normal >10 mg/dl) values were also gathered. Statistical analysis was performed using Pearson and Spearman correlation coefficient. Significance level was set as <0.05.

Results Twenty-one patients were included, with a mean current age of 26,6 years (±7,44). Two patients were male (9,5%). Eleven patients (52,4%) had renal involvement: 9 with lupus nephritis class IV, 1 with class III and 1 with class II. More than half of them (63,6%) were in maintenance treatment with mycophenolate mofetil. Considering laboratory measurements, the mean serum 25OH-D was 22,1 ng/ml (±9,36), mean C4 17,5 mg/dl (±7,29) and median C3c 105 mg/dl (from 18 to 144 mg/dl). Only 14,3% (n=3) had serum 25OH-D above 30 ng/ml; 19,0% (n=4) had low C3c levels and 9,5% (n=2) low C4 levels. When correlating 25OH-D with C3c values, no statistical significant difference was found (r=0,005; p=0.9843). The same occurred with 25OH-D and C4 (r=0,127; p=0.5843).

Conclusion Vitamin D has an important role on the immune system modulation, but still not fully understood. In SLE, other authors have described a positive correlation between serum levels of 25OH-D and complement components levels. Despite the small sample size, this hypothesis was not confirmed in the presented population.

  • Juvenile SLE
  • Vitamin D
  • Complement

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