GG-01 Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T cells is associated with type-I interferon-dependent HLA-DRB1 overexpression and activation of autologous CD4+ T cells in systemic lupus erythematosus

Shaylynn Miller; Patrick Coit; Elizabeth Gensterblum-Miller; Paul Renauer; Nathan C Kilian; Mark Schonfeld; Pei-Suen Tsou; Amr H Sawalha

doi:10.1136/lupus-2018-lsm.88

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Genetics, Genomics and Epigenetics

GG-01 Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T cells is associated with type-I interferon-dependent HLA-DRB1 overexpression and activation of autologous CD4+ T cells in systemic lupus erythematosus

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Shaylynn Miller Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Patrick Coit Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Elizabeth Gensterblum-Miller Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Paul Renauer Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Nathan C Kilian Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Mark Schonfeld Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Pei-Suen Tsou Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Amr H Sawalha Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA PubMed articles Google scholar articles

Citation

Miller S, Coit P, Gensterblum-Miller E, et al

Lupus Science & Medicine 2018;5:doi: 10.1136/lupus-2018-lsm.88

Publication history

First published September 4, 2018.

Online issue publication

May 13, 2022

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