Article Text
Abstract
Objective Epidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations.
Methods MLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture–recapture analyses were conducted to assess case under-ascertainment.
Results Based on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture–recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition.
Conclusion Data from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.
- epidemiology
- Discoid Lupus Erythematosus
- Registry
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Footnotes
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Presented at This manuscript is based on work previously presented at the 2018 American College of Rheumatology annual meeting and published as a conference abstract: Izmirly PM, Buyon JP, Belmont HM, Sahl S, Wan I, Salmon JE, Askanase A, Bathon J, Geraldino-Pardilla L, Ali Y, Ginzler EM, Putterman C, Gordon C, Helmick CG, Parton H. Preliminary population-based incidence and prevalence estimates of primary discoid lupus and cutaneous lupus erythematosus from the Manhattan Lupus Surveillance Program [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10).
Contributors Study conception and design: PI, CG, CH, HP. Acquisition of data: PI, JB, IW, HMB, SS, JS, AA, JMB, LG-P, YA, EG, CP, HP. Analysis and interpretation of data: PI, JB, CH, HP.
Funding This work was supported by co-operative agreements between the Centers for Disease Control and Prevention and The New York City Department of Health and Mental Hygiene (grant no. U58/DP002827) and a co-operative agreement between the New York City Department of Health and Mental Hygiene and New York University School of Medicine.
Disclaimer The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval NYC DOHMH IRB no. 16-147.
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement No data are available.