Article Text

Download PDFPDF

72 Lupus impact tracker is responsive to changes in physician (T2T) and patient (SLAQ, EQ5D) relevant outcomes in a large spanish lupus registry cohort
  1. Iñigo Rua Figueroa1,
  2. Herve Devilliers2,
  3. Jose Maria Pego Reigosa3,
  4. Irene Altabás González4,
  5. Javier Narváez-García5,
  6. Francisco Javier López-Longo6,
  7. Juan Ovalles-Bonilla6,
  8. Jaime Calvo Alen7,
  9. Maria Galindo Izquierdo8,
  10. Antonio Fernandez Nebro9,
  11. Mónica Ibáñez-Barcelo10,
  12. Carlos Montilla Morales11,
  13. Mª Jesús García-Villanueva12,
  14. Paloma Vela-Casasempere13,
  15. María E Ruiz-Lucea14,
  16. Francisco J Toyos-Sáenz-de-Miera15,
  17. José A Hernández-Beriaín16,
  18. Elvira Díez-Álvarez17,
  19. Joel Block18 and
  20. Meenakshi Jolly18
  1. 1Hospital De Gran Canaria dr. Negrín
  2. 2Centre Hospitalier Universitaire de Dijon
  3. 3Complexo hospitalario Universitario Vigo
  4. 4Hospital Do Meixoeiro
  5. 5Hospital de Bellvitge
  6. 6Hospital General Universitario Gregorio Marañón
  7. 7Hospital Universitario Araba
  8. 8Hospital Universitario 12 De Octubre
  9. 9UGC de Reumatología, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Spain
  10. 10Hospital Son Llàtzer De Palma De Mallorca
  11. 11Hospital Clinico Universitario Salamanca
  12. 12Hospital Ramón Y Cajal
  13. 13Hospital General De Alicante
  14. 14Hospital De Basurto
  15. 15Hospital Virgen De La Macarena
  16. 16Hospital Insular De Gran Canaria
  17. 17Hospital De León
  18. 18Rush University Medical Center


Background Remission and Low Disease activity state (LDAS) are physician assessed treat to target-T2T outcomes for Systemic Lupus Erythematosus (SLE). Lupus Impact Tracker (LIT), a ten-item unidimensional patient reported tool has good psychometric properties and responds to patient reported changes in health, physician based disease activity (DA) and composite response Index (SRI). Herein we report responsiveness of LIT to changes in physician (T2T) and patient assessed outcomes (DA by SLAQ and health status (EQ5D)) among SLE patients from the largest European SLE registry- cohort.

Methods One-year longitudinal, observational, multi-center data from 1364 adult patients with SLE meeting 1997 ACR criteria were obtained from baseline and year 1 visit. This included demographics, patient reported tools (LIT, EQ5D VAS, SLAQ), SLE (activity-SLEDAI) and medications. Remission off therapy (ROFT) was defined as SLEDAI=0 without prednisone or Immunosuppressive/s. Remission on-therapy (RONT) was SLEDAI=0 and a prednisone dose 5 mg/day and/or Immunosuppressive/s (maintenance dose). LDAS (modified) was defined as SLEDAI 4, prednisone dose 9 mg/day and/or maintenance immunosuppressive/s. Non-optimal (NO) disease status was SLEDAI >4 and/or prednisone dose >9 mg/day and/or immunosuppressive/s in induction dose. Use of hydroxychloroquine was permitted in all groups. LIT values were compared using mixed models. Responsiveness was evaluated by standard response means (SRM) in groups with changes in DA (T2T, SLAQ) and EQ5D VAS as anchors. We did not have enough observations for stratified analysis for SLE patients with fibromyalgia.

Results 1232/1364 (90%) were women, and 95% were Caucasian. Mean (SD) SLEDAI and SDI were 2.6 (3.5) and 0.7 (1.1) respectively. As (i) DA was low (median 2) in LDAS, (ii) steroid use was more prevalent in RONT than LDAS, we combined RONT and LDAS into one category to analyse patient relevant differences in LIT.

LIT was responsiveness in the appropriate direction with improvement and worsening in disease activity (T2T and SLAQ) and health status (EQ5D VAS) over time. Mean LIT changes to and from NO to RONT/LDAS ranged from 3–5 (table 1), while it declined by over 8.5 with change from NO to ROFT. We had limited observations for ROFT to NO change. Mean change in LIT ranged from −3 to 3 with improvement and worsening in SLAQ, and from −7.6 to 6 with improvement and worsening in EQ5D VAS.

Abstract 72 Table 1

LIT Responsiveness against various anchors stratified by FM status in SLE

Conclusions LIT responds appropriately in both directions to changes in physician (T2T) as well as patient relevant (DA and health status) outcomes among Spanish SLE patients.

Funding Source(s): None

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.