Background Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease. It may affect adults and paediatric patients and may have different organ involvement at onset of disease.

Objectives To study disease profile of 100 adult and paediatric SLE patients at disease onset to find any significant difference in organ involvement in both cohorts.

Method 100 adult and 100 paediatric patients who classified SLE-SLICC criteria were recruited in study after taking consent at tertiary care centre in northern India. Demographic data and clinical profiles were recorded. Fisher’s test was used to find p value and p value less than 0.05 was taken as statistical significance.

Results Out of 100 patients, females were 85% in adult cohort Vs 76% in paediatric cohort. Median delay in diagnosis was more with adult than paediatric cases. Lupus nephritis, mouth ulcers, NPSLE was common in paediatric SLE patients. In adult cohort, there was significant association for fatigue, RP, and thrombosis.

Conclusion Major organ involvement was frequent in adult patients while arthritis, leukopenia, low complements, more positivity of anti-dsDNA, APLA antibodies positivity were significantly common in paediatric cases.