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P149 Association between geographic and climatological conditions and cutaneous manifestations in lupus patients from the Spanish rheumatology society lupus registry cohort
  1. Raúl Menor-Almagro1,
  2. Alejandro Muñoz2,
  3. Iñigo Rúa-Figueroa3,
  4. María Auxiliadora Martín-Martínez4,
  5. Alejandro Olivé5,
  6. María Galindo6,
  7. Jaime Calvo-Alén7,
  8. Antonio Fernández-Nebro8,
  9. Javier López-Longo9,
  10. Mariano Andrés10,
  11. Eva Tomero11,
  12. Esther Uriarte12,
  13. Mercedes Freire13,
  14. Javier Narváez14,
  15. José María Pego-Reigosa15,
  16. on behalf of RELES-SER
  1. 1Rheumatology, Hospital Jerez, Jerez
  2. 2Rheumatology, Hospital Virgen del Rocío, Sevilla
  3. 3Rheumatology, Hospital Doctor Negrín, Las Palmas GC
  4. 4Research Unit, Sociedad Española de Reumatología, Madrid
  5. 5Rheumatology, Hospital Germans Trias i Pujol, Badalona
  6. 6Rheumatology, Hospital 12 de Octubre, Madrid
  7. 7Rheumatology, Hospital Txagorritxu, Vitoria
  8. 8Rheumatology, Hospital Regional Universitario Málaga, Málaga
  9. 9Rheumatology, Hospital Gregorio Marañón, Madrid
  10. 10Rheumatology, Hospital Alicante, Alicante
  11. 11Rheumatology, Hospital La Princesa, Madrid
  12. 12Rheumatology, Hospital Donostia, Donostia
  13. 13Rheumatology, Hospital Juan Canalejo, A Coruña
  14. 14Rheumathology, Hospital Bellvitge, Barcelona
  15. 15Hospital Meixoeiro, Vigo, Spain


Background/Purpose Ultraviolet radiations act by modifying DNA in sun-exposed skin of lupus patients. We develop a study to analyze the association between climatological conditions and cutaneous manifestations in systemic lupus erythematosus (SLE).

Methods Patients data from Spanish Rheumatology Society Lupus Registry (RELESSER) cohort were retrospectively analyzed for presence of cutaneous lesions (alopecia, photosensitivity, malar rash, discoid lesions, oral ulcers and subacute lesions). We included patients who were assessed in rheumatology services from January 2011 to December 2012. Data of climatological conditions throughout the Spanish geography were provided by the Spanish Meteorological Agency.

Results A total of 2919 patients were included, 87.3% female. Others biological and clinical data are showed in table 1. In the multivariable model, positive associations were observed between coastal regions OR 1.470 (95% CI:1.080–2.001 p=0,014), anti-DNA OR 1.806 (95% CI:1.276–2.556, p=0.001), antiphospholipids antibodies OR 1.428 (95% CI:1.093–1.864 p=0.009), serositis OR 1.557 (95% CI:1.181–2.053 p=0.002) and arthritis OR 1.804 (95% CI:1.258–2.587 p=0,001). Negative associations were observed between females OR 0.412 (95% CI:0.284–0.599, p=0.000) and antimalarial drugs OR 0.469 (95% CI:0.327–0.671, p=0.000).

Abstract P149 Table 1

Geographical, climatological, biologic and clinical patients characteristics

Conclusion Although the influence of global and ultraviolet radiations on the development of cutaneous lesions in SLE have been suggested, the results of our study does not support an association between the diverse climatological conditions and cutaneous manifestations in SLE. However we observed an independent association with living in coastal areas.

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