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P191 Chinese systemic lupus erythematosus treatment and research group (CSTAR) registry – subjective well-being in patients with systemic lupus erythematosus
  1. Yue Shi1,
  2. Dandan Bi2,3,
  3. Yanhong Wang4,
  4. Ruofan Li5,
  5. Lijun Wu6,
  6. Cheng Zhao7,
  7. Zhenbiao Wu8,
  8. Xinwang Duan9,
  9. Jian Xu10,
  10. Feng Zhan11,
  11. Min Yang12,
  12. Shengyun Liu13,
  13. Qin Li14,
  14. Shuo Zhang1,
  15. Lingshan Liu1,
  16. Jiuliang Zhao1,
  17. Xinping Tian1,
  18. Xinying Li2,3,
  19. Qian Wang1,
  20. Xiaofeng Zeng1 and
  21. CSTAR Co-authors
  1. 1Dept. of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Ministry of Science and Technology, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing
  2. 2CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing
  3. 3University of Chinese Academy of Sciences, Beijing
  4. 4Dept. of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing
  5. 5Dept. of International Education, The Experimental High School Attached to Beijing Normal University, Beijing
  6. 6Dept. of Rheumatology, The People’s Hospital of Xinjiang Autonomous, Urumqi
  7. 7Dept. of Rheumatology, First Affiliated Hospital of Guangxi Medical University, Nanning
  8. 8Dept. of Clinical Immunology and Rheumatology, Xijing Hospital Affiliated with The Fourth Military Medical University, Xi’An
  9. 9Dept. of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang
  10. 10Dept. of Rheumatology, First Affiliated Hospital of Kunming Medical University, Kunming
  11. 11Dept. of Rheumatology, Hainan Provincial People’s Hospital, Haikou
  12. 12Dept. of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou
  13. 13Dept. of Rheumatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou
  14. 14Dept. of Rheumatology, The First People’s Hospital of Yunnan Province, Kunming, China


Objectives Systemic lupus erythematosus (SLE) can significantly influence patients’ quality of life and subjective wellbeing (SWB). This study compared SWB statuses in SLE patients and analysed their relationship with clinical manifestations, emotional variables and related positive factors.

Methods Overall, 1779 SLE patients from the Chinese SLE Treatment and Research Group (CSTAR) and 203 age and gender-matched individuals from the general population without self-reported SLE were invited to complete measures of SWB, emotional variables and related positive factors. These patients’ clinical data in CSTAR were also linked to investigate the influence of clinical manifestations and psychological factors on SWB among SLE patients.

Results SWB, self-efficacy and resilience were significantly lower (P<0.001) in SLE patients than in the general population, and self-esteem, depression and anxiety were significantly higher (P<0.001). Among the SLE patients, life satisfaction was significantly positively correlated with patients’ age (P<0.001) and the age at diagnosis (P<0.001) and negatively correlated with SLE disease activity index (SLEDAI) (P<0.05). Premature gonadal failure (PGF) (P<0.05) was significantly associated with positive and negative affect scores. In active SLE patients with SLEDAI≥4, depression and resilience were life satisfaction predictors. However, anxiety, self-esteem and resilience predicted life satisfaction changes in in patients with SLEDAI<4.

Conclusion SWB provides useful insight into the impact of SLE on mental health and opportunities to improve quality of life and clinical care. PGF and disease activity emerge as are predictors of SWB status and potential therapeutic targets to develop positive attitude in SLE patients.

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