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P85 The IRF5 (rs729302) polymorphism is a genetic risk factor for systemic lupus erythematosus in Algerian patients
  1. Ines Allam1,
  2. Aldjia Lamri2,
  3. Sihem Oulacrouz2,
  4. Mohamed Saidani2 and
  5. Reda Djidjik1
  1. 1Dept. of Immunology, Beni Messous Hospital, Algiers
  2. 2Dept. of nephrology, Beni Messous Hospital, Algiers, Algeria


Background Interferon regulatory factor 5 (IRF5) is a transcription factor regulating interferon secretion and was proved to be implicated in the pathogenesis of systemic lupus erythematosus (SLE) in several studies.

The purpose of this case-control study was to investigate whether IRF5 gene polymorphism is involved in the genetic predisposition to SLE in the Algerian population.

Methods IRF5 rs729302 (A/C) polymorphism was analyzed in 120 SLE patients and 98 age and sex matched controls by real time- polymerase chain reaction.

Results Significant association was observed for AA and AC genotypes of IRF5 between patients and healthy subjects (60% vs 73%; 40% vs 27%, p =0.025, respectively).

Patients with SLE had more frequent C allele compared to controls (20% vs 13%, P = 0.041).

However, the allele and genotype frequencies did not show any difference in patients with nephritis in comparison to those without nephritis.

Conclusion The rs729302 C allele and AC genotype can be considered as risk factors for the development of SLE in Algerian patients.

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