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P111 Health-related quality of life assessed by LupusQoL questionnaire and SF-36 in Russian patients with systemic lupus erythematosus
  1. Elena Aseeva,
  2. Lyubov Vorobyova,
  3. Sergei Soloviev and
  4. Svetlana Glukhova
  1. Intensive Care Dept., V.A. Nasonova Research Institute of Rheumatology, Moscow, Russian Federation


The LupusQoL is a disease-specific health-related quality of life (HRQoL) measure for patients with lupus. We conducted this study to compare the efficiency of LupusQoL with the 36-item Short-Form Health Survey (SF-36), a generic quality of life (QoL) scale, in Russian patients with lupus. Both questionnaires were conducted at a single visit to the clinic. Disease activity was evaluated by the SLEDAI-2K, and chronic damage by the Systemic Lupus International Collaborating Clinics Damage Index score (SDI). Associations between the LupusQoL and SF-36 domains were examined, while also examining age, disease duration, and disease activity for each questionnaire. Descriptive statistics, Spearman’s correlation coefficients, and Students t test were performed to analyze the data.

A total of 328 patients with lupus (F/M 298:30, mean age 34,4±11.5 years, mean disease duration 106,3±91,9.0 months) were included, and 65,3% of these were active and 56,5% of these had SDI≥1. The mean SLEDAI 2K score was 9,6±8,0.

QOL as assessed by SF-36 and LupusQoL was low in this group of patients with SLE. The mean scores for each of the domains of the LupusQoL and SF-36 are shown in table 1. The mean scores are <60 in 8 domains of the SF-36 but not in social functioning (62,03±27,19) and physical function (62,35±28,53).

Abstract P111 Table 1

Descriptive statistics and correlation coefficient for SF-36 and LupusQol

The MCS and PCS scores were both <50. Despite the fact that the mean score in LupusQoL was always higher than in SF-36 for each of the comparable domains, 3 standardized p values were not statistically significant (mean score in 328 patient visits: physical health/physical function, 66,20±23,18/62,35±28,53, p = 0.96; emotional health/mental health, 64,65±24,75/50,51±8,40, p=0.94; and fatigue/vitality 62.70±24.73/53.04±22.59, p=0.83), 1 standardized p values was statistically significant pain/bodily pain 70.03±24.68/47.00±8.86, p=0.02. The correlation of the comparable domains of LupusQoL and SF-36 was studied. There was a strong correlation between comparable domains in LupusQoL and SF-36 in 328 patient visits (physical health and physical functioning, r=0.77; emotional health and role emotional, r=0.38; pain and bodily pain, r=-0,33; and fatigue and vitality, r=-0.70; all p values <0.0001).

For the 4 non-comparable domains of the LupusQoL, there was a correlation between 3 domain of LupusQoL and 1 of the component scores of SF-36: body image and SF-36 MCS, r=0.20; planning and SF-36 MCS, r=0.13, r=0.73; and burden to others and SF-36 MCS, r=0.19; body image and SF-36 PCS, r=0,38; planning and SF-36 PCS, r=0,66; and burden to others and SF-36 PCS, r=0,38.

The Lupus Qol scales such as: pain, planning, intimate relationships, burden to others and bodily image correlated with disease activity (by SLEDAI 2K).

Conclusions The LupusQoL-Russian is sensitive to change in SLE patients with active SLE. LupusQoL and SF-36 were equivalent in assessing the HRQOL in Russian SLE patients. Both LupusQoL and SF-36 are easily completed by patients and correlate very well with each other.

The HRQOL by LupusQoL-Russian strongly correlated with disease activity.

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