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P145 Membranous and proliferative lupus nephritis – analysis of a nationwide multicentre cohort
  1. Filipa Farinha1,
  2. Sofia Barreira2,
  3. Maura Couto3,
  4. Margarida Cunha4,
  5. Diogo Fonseca5,
  6. Raquel Freitas4,
  7. Luís Inês6,
  8. Mariana Luís6,
  9. Carla Macieira2,
  10. Joana Rodrigues7,
  11. Bernardo Santos8,
  12. Rita Torres9,
  13. Ruth Pepper10,
  14. Anisur Rahman1 and
  15. Maria J Santos4
  1. 1Rheumatology, UCL, London,UK
  2. 2Rheumatology, Centro Hospitalar Universitário Lisboa Norte, Lisbon
  3. 3Rheumatology, Centro Hospitalar Tondela-Viseu, Viseul
  4. 4Rheumatology, Hospital Garcia de Orta, Almada
  5. 5Rheumatology, Centro Hospitalar de Vila Nova de Gaia/Espinho, Espinho
  6. 6Rheumatology, Centro Hospitalar Universitário de Coimbra, Coimbra
  7. 7Rheumatology, Unidade Local de Saúde do Alto Minho, Ponte de Lima
  8. 8Rheumatology, Centro Hospitalar Baixo Vouga, Aveiro
  9. 9Rheumatology, Hospital Egas Moniz-CHLO, Lisbon, Portugal
  10. 10Nephrology, UCL, London, UK


Background Lupus Nephritis (LN) is one of the most severe manifestations of Systemic Lupus Erythematosus (SLE). We aimed to compare proliferative (PLN), membranous (MLN) and mixed LN regarding clinical and laboratory presentation, and serologic profiles. Previous work suggested that these groups differ in autoantibody profile and complement levels, but those reports mainly originate from single-centres.

Methods Multicentre observational study, with retrospective analysis of a prospective cohort, using data from the Portuguese registry of rheumatic diseases– Patients with biopsy-proven PLN, MLN and mixed LN were included. The first renal biopsy showing one of these classes was considered, for each patient. Groups were compared using Pearson’s Chi-Square for categorical variables and One-Way ANOVA or Kruskal-Wallis for numerical variables.

Abstract P145 Table 1

Comparative description of patients with proliferative, membranous and mixed LN enrolled in – the Portuguese registry of rheumatic disease covering over 20 centres throughout Portugal

Results 232 patients were included (87% females; 88.5% White Europeans). Median follow-up was 7 years (IQR 10.75; maximum 35 years). As seen in table1, the level of proteinuria did not differ between groups; however, MLN patients presented with significantly lower creatinine. Levels of complement were reduced in PLN and mixed LN but were normal in MLN patients, and this difference was statistically significant. Groups also differed regarding the proportion of positivity for anti-dsDNA (higher in PLN) and anti-RNP antibodies (higher in MLN). There was a lower SLEDAI in MLN, probably linked with the lower prevalence of anti-dsDNA antibodies and complement consumption in this group.

Conclusions Our results support previous findings from single-centre studies suggesting that MLN has a different serological profile than PLN, possibly reflecting different pathogenesis.

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