‘Eclectic’, what a great word to describe the approaches to the development of drugs in systemic lupus erythematosus (SLE)! ‘Eclectic’ comes from a Greek verb meaning ‘to select’ and was originally applied to ancient philosophers who were not committed to any single system of philosophy; instead, these philosophers selected whichever doctrines pleased them from every school of thought.1 Much like the ancient Greek philosophers, drug target selection in SLE has spanned many pathways. Although belimumab has been the sole drug approved to date via the traditional route of a randomised controlled trial, it’s just a matter of time before drugs targeting other molecules and pathways are granted approval for SLE and lupus nephritis.
The potential drug targets in SLE appear limitless, making decisions regarding resource allocation incredibly challenging. Should components of the innate or the adaptive immune system be targeted? Perhaps both? This presentation will review various strategies being pursued in order to inhibit key pathways in SLE. The emphasis will be on investigational agents in Phase I and Phase II programmes.2–7
Describe strategies for inhibiting the type I interferon pathway
Discuss methods to target B and T cells
Review approaches to down-regulate pro-inflammatory cytokines
Merriam-Webster Unabridgedaccessed June 19, 2020.
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