Lupus Science & Medicine: 8 (1)

Animal models

Original research: Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model (20 May, 2021)
Masashi Fukuta, Kotaro Suzuki, Shotaro Kojima, Yoko Yabe, Kazumasa Suzuki, Kazuma Iida, Hiroyuki Yamada, Shinichi Makino, Arifumi Iwata, Shigeru Tanaka, Taro Iwamoto, Akira Suto, Daiki Nakagomi, Hidefumi Wakashin, Yuko Maezawa, Yoshiro Maezawa, Minoru Takemoto, Katsuhiko Asanuma, Hiroshi Nakajima

Cutaneous lupus

Original research: Cutaneous lupus concerns from the patient perspective: a qualitative study (27 August, 2021)
Daisy Yan, Danielle Zamalin, Srita Chakka, Rebecca Krain, Josef Concha, Rui Feng, Sarah Ahmed, Joyce Okawa, Victoria P Werth

Brief communication

Absence of renal remission portends poor long-term kidney outcome in lupus nephritis (26 August, 2021)
Valérie Pirson, Antoine Enfrein, Frédéric A Houssiau, Farah Tamirou
SARS-CoV-2 vaccines in patients with SLE (8 March, 2021)
Wei Tang, Anca D Askanase, Leila Khalili, Joan T Merrill
Patient and provider perceptions of a novel cognitive functioning report for patients with systemic lupus erythematosus: a qualitative study (24 February, 2021)
Laura Plantinga, Ann Vandenberg, Felicia Goldstein, Brian Jones, Jeremy Johnson, Christopher Barrett Bowling, Charmayne Dunlop-Thomas, Sung Sam Lim, Cristina Drenkard

Biomarker studies

Original research: A multianalyte assay panel with cell-bound complement activation products demonstrates clinical utility in systemic lupus erythematosus (12 July, 2021)
Roberta Vezza Alexander, Daniel Scott Rey, John Conklin, Vinicius Domingues, Mansoor Ahmed, Jazibeh Qureshi, Arthur Weinstein
Original research: Anxiety and depression severity in neuropsychiatric SLE are associated with perfusion and functional connectivity changes of the frontolimbic neural circuit: a resting-state f(unctional) MRI study (29 April, 2021)
Despina Antypa, Nicholas J Simos, Eleftherios Kavroulakis, George Bertsias, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios Boumpas, Efrosini Papadaki
Original research: Hydroxychloroquine is associated with lower platelet activity and improved vascular health in systemic lupus erythematosus (18 March, 2021)
MacIntosh Grant Cornwell, Elliot S Luttrell-Williams, Michael Golpanian, Hanane El Bannoudi, Khrystyna Myndzar, Peter Izmirly, H Michael Belmont, Stuart Katz, Nathaniel R Smilowitz, Alexis Engel, Robert Clancy, Kelly Ruggles, Jill P Buyon, Jeffrey S Berger
Original research: RNA tape sampling in cutaneous lupus erythematosus discriminates affected from unaffected and healthy volunteer skin (3 March, 2021)
Joseph F Merola, Wenting Wang, Carrie G Wager, Stefan Hamann, Xueli Zhang, Alice Thai, Christopher Roberts, Christina Lam, Cristina Musselli, Galina Marsh, Dania Rabah, Catherine Barbey, Nathalie Franchimont, Taylor L Reynolds

Co-morbidities

Original research: Characteristics of cardiovascular autonomic dysfunction and association with quality of life in patients with systemic lupus erythematosus (22 July, 2021)
Amanda Hempel Zinglersen, Katrine Kjær Iversen, Henrik Christian Bidstrup Leffers, Esben Laugesen, Jesper Fleischer, Søren Jacobsen
Original research: Myocardial infarctions, subtypes and coronary atherosclerosis in SLE: a case–control study (21 July, 2021)
Isak Samuelsson, Ioannis Parodis, Iva Gunnarsson, Agneta Zickert, Claes Hofman-Bang, Håkan Wallén, Elisabet Svenungsson
Original research: Cardiovascular complications of systemic lupus erythematosus: impact of risk factors and therapeutic efficacy—a tertiary centre experience in an Appalachian state (5 May, 2021)
Elise Danielle McVeigh, Amna Batool, Arnold Stromberg, Ahmed Abdel-Latif, Nayef Mohammed Kazzaz
Original research: Patients with SLE have higher risk of cardiovascular events and mortality in comparison with controls with the same levels of traditional risk factors and intima-media measures, which is related to accumulated disease damage and antiphospholipid syndrome: a case–control study over 10 years (5 February, 2021)
Sofia Ajeganova, Ingiäld Hafström, Johan Frostegård
Original research: Intracellular homocysteine metabolites in SLE: plasma S-adenosylhomocysteine correlates with coronary plaque burden (21 January, 2021)
George Stojan, Jessica Li, Tian Liu, Maureen A Kane, Michelle A Petri

Clinical trials and drug discovery

Original research: Peripheral neuropathy in systemic lupus erythematosus: what can neuromuscular ultrasonography (NMUS) tell us? A cross-sectional study (26 July, 2021)
Safaa A Mahran, Felice Galluccio, Tayseer Mohamed Khedr, Amira Elsonbaty, Abdallah El-Sayed Allam, Alvaro Garcia Martos, Doaa M M Osman, Marco Matucci-Cerinic, Serena Guiducci, Marwa A A Galal
Original research: Lupus clinical trial eligibility in a real-world setting: results from the British Isles Lupus Assessment Group-Biologics Register (BILAG-BR) (23 July, 2021)
Sarah Dyball, Sophie Collinson, Emily Sutton, Eoghan M McCarthy, Ian N Bruce, Ben Parker
Original research: Safety profile of anifrolumab in patients with active SLE: an integrated analysis of phase II and III trials (17 February, 2021)
Raj Tummala, Gabriel Abreu, Lilia Pineda, M Alex Michaels, Rubana N Kalyani, Richard A Furie, Eric F Morand

Childhood lupus

Original research: Formal neurocognitive function and anti-N-methyl-D-aspartate receptor antibodies in paediatric lupus (23 March, 2021)
Tamara K Nowling, Mary Kral, Bethany Wolf, Gary Gilkeson, Natasha McKerran Ruth

Epidemiology and outcomes

Original research: Frequency, severity and costs of flares increase with disease severity in newly diagnosed systemic lupus erythematosus: a real-world cohort study, United States, 2004–2015 (23 September, 2021)
Edward R Hammond, Barnabas Desta, Aimee M Near, Xia Wang, Miao Jiang
Original research: Achieving remission or low disease activity is associated with better outcomes in patients with systemic lupus erythematosus: a systematic literature review (21 September, 2021)
Manuel Francisco Ugarte-Gil, Claudia Mendoza-Pinto, Cristina Reátegui-Sokolova, Guillermo J. Pons-Estel, Ronald F van Vollenhoven, George Bertsias, Graciela S. Alarcon, Bernardo A Pons-Estel
Original research: Infection hospitalisation in systemic lupus in Sweden (15 September, 2021)
Julia F Simard, Marios Rossides, Iva Gunnarsson, Elisabet Svenungsson, Elizabeth V Arkema
Original research: Disease and economic burden increase with systemic lupus erythematosus severity 1 year before and after diagnosis: a real-world cohort study, United States, 2004–2015 (14 September, 2021)
Miao Jiang, Aimee M Near, Barnabas Desta, Xia Wang, Edward R Hammond
Original research: Evaluation of SLE arthritis using frequency domain optical imaging (30 August, 2021)
Alessandro Marone, Wei Tang, Youngwan Kim, Tommy Chen, George Danias, Cathy Guo, Yevgeniya Gartshteyn, Leila Khalili, Hyun Kim, Andreas Hielscher, Anca D Askanase
Original research: Comorbidity and healthcare utilisation in persons with incident systemic lupus erythematosus followed for 3 years after diagnosis: analysis of a claims data cohort (25 August, 2021)
Katinka Albrecht, Imke Redeker, Martin Aringer, Ursula Marschall, Anja Strangfeld, Johanna Callhoff
Original research: Use of a screening questionnaire for systemic lupus erythematosus among pregnant women in a Mexican population (22 June, 2021)
Luis Lucero-Morales, Juanita Romero-Diaz, Diana Yazmin Copado-Mendoza, María del Carmen Zamora-Medina, Sandra Acevedo-Gallegos, Juan Manuel Gallardo-Gaona, Berenice Velazquez-Torres, Jose Antonio Ramirez-Calvo, Dulce Maria Camarena-Cabrera, Maria Jose Rodriguez-Sibaja
Original research: Assessment of cardiovascular risk tools as predictors of cardiovascular disease events in systemic lupus erythematosus (27 May, 2021)
Jagan Sivakumaran, Paula Harvey, Ahmed Omar, Oshrat Tayer-Shifman, Murray B Urowitz, Dafna D Gladman, Nicole Anderson, Jiandong Su, Zahi Touma
Original research: The Care-coordination Approach to Learning Lupus Self-Management: a patient navigator intervention for systemic lupus inpatients (11 May, 2021)
Ashley A White, Aissatou Ba, Trevor Daniel Faith, Viswanathan Ramakrishnan, Clara L Dismuke-Greer, Jim C Oates, Edith Marie Williams
Original research: Quick Systemic Lupus Activity Questionnaire (Q-SLAQ): a simplified version of SLAQ for patient-reported disease activity (10 May, 2021)
Elisabet Svenungsson, Iva Gunnarsson, Vera Illescas-Bäckelin, Estelle Trysberg, Andreas Jönsen, Dag Leonard, Christopher Sjöwall, Susanne Pettersson
Original research: Evaluation of structured data from electronic health records to identify clinical classification criteria attributes for systemic lupus erythematosus (26 April, 2021)
Theresa L Walunas, Anika S Ghosh, Jennifer A Pacheco, Vesna Mitrovic, Andy Wu, Kathryn L Jackson, Ryan Schusler, Anh Chung, Daniel Erickson, Karen Mancera-Cuevas, Yuan Luo, Abel N Kho, Rosalind Ramsey-Goldman
Original research: Hydroxychloroquine availability during COVID-19 crisis and its effect on patient anxiety (19 April, 2021)
Alain Cornet, Jeanette Andersen, Chiara Tani, Marta Mosca
Original research: Living with systemic lupus erythematosus in 2020: a European patient survey (13 April, 2021)
Alain Cornet, Jeanette Andersen, Kirsi Myllys, Angela Edwards, Laurent Arnaud
Original research: Smoking associates with distinct clinical phenotypes in patients with systemic lupus erythematosus: a nationwide Danish cross-sectional study (2 April, 2021)
Henrik Christian Bidstrup Leffers, Anne Troldborg, Anne Voss, Salome Kristensen, Jesper Lindhardsen, Prabhat Kumar, Asta Linauskas, Lars Juul, Niels Steen Krogh, Bent Deleuran, Lene Dreyer, Søren Jacobsen
Original research: Hydroxychloroquine treatment in European patients with lupus erythematosus: dosing, retinopathy screening and adherence (1 April, 2021)
Zgjim Osmani, Thijs J Schrama, Wendy Zacouris-Verweij, Jeanette Andersen, Susan Frankel, Irene E M Bultink, Alain Cornet, Ronald F van Vollenhoven
Original research: The ALPHA Project: Establishing consensus and prioritisation of global community recommendations to address major challenges in lupus diagnosis, care, treatment and research (9 February, 2021)
Karin Tse, Sanjyot Sangodkar, Lauren Bloch, Kathleen Arntsen, Sang-Cheol Bae, Ian N Bruce, Erin Connolly-Strong, Karen H Costenbader, Bradley Dickerson, Thomas Dörner, Sydney Evans, Kenneth Kalunian, Amy H Kao, Susan Manzi, Eric F Morand, Sandra C Raymond, Brad H Rovin, Laura Eve Schanberg, Joan M Von Feldt, Victoria P Werth, Angel Williams Derricott, David Zook, Timothy Franson, Kenneth Getz, Yaritza Peña, Leslie M Hanrahan
Original research: Within-trial economic analysis of flare data from the BLISS-SC trial of subcutaneous belimumab in systemic lupus erythematosus (8 February, 2021)
Tasneem Lokhandwala, Binglin Yue, Anna D Coutinho, Christopher F Bell

Genetics

Original research: Apolipoprotein L1 risk genotypes in Ghanaian patients with systemic lupus erythematosus: a prospective cohort study (18 January, 2021)
Ashira Blazer, Ida Dzifa Dey, Janet Nwaukoni, Margaret Reynolds, Festus Ankrah, Huda Algasas, Tasneem Ahmed, Jasmin Divers

Immunology and inflammation

Original research: Combining C reactive protein and serum albumin to predict 90-day mortality in systemic lupus erythematosus with serious community-acquired infections (12 July, 2021)
Shuangjun He, Chao Tang, Jie Yu, Jun Ma, Minjie Qiao, Wei Zhou, Yi Chen, Xingyu Zhang
Original research: Impact of systemic lupus erythematosus disease activity, hydroxychloroquine and NSAID on the risk of subsequent organ system damage and death: analysis in a single US medical centre (8 April, 2021)
Deanna D Hill, Amanda M Eudy, Peter J Egger, Qinggong Fu, Michelle A Petri
Original research: Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus (16 March, 2021)
Felice Rivellese, Sotiria Manou-Stathopoulou, Daniele Mauro, Katriona Goldmann, Debasish Pyne, Ravindra Rajakariar, Patrick Gordon, Peter Schafer, Michele Bombardieri, Costantino Pitzalis, Myles J Lewis
Original research: Activated low-density granulocytes in peripheral and intervillous blood and neutrophil inflammation in placentas from SLE pregnancies (8 March, 2021)
Marit Stockfelt, Gunilla Larsson, Hanna Engström, Henri Puttonen, Henrik Zetterberg, Kaj Blennow, Christopher Sjöwall, Helena Strevens, Andreas Jönsen, Anders A Bengtsson, Maria Majczuk Sennström, Agneta Zickert, Elisabet Svenungsson, Iva Gunnarsson, Estelle Trysberg, Bo Jacobsson, Anna-Karin Hultgård Ekwall, Karin Christenson, Johan Bylund, Mattias N D Svensson, Anna-Carin Lundell
Original research: Efficacy of belimumab in two serologically distinct high disease activity subgroups of patients with systemic lupus erythematosus: post-hoc analysis of data from the phase III programme (10 February, 2021)
Toni Maslen, Ian N Bruce, David D'Cruz, Mihaela Ianosev, Damon L Bass, Christel Wilkinson, David A Roth

Letter

Canadian workplace experiences of systemic lupus erythematosus (SLE) (21 September, 2021)
Francesca S Cardwell, Jenna Dixon, Ann E Clarke, Susan J Elliott
Personalised therapy during preconception and gestation in SLE: usefulness of 6-mercaptopurine metabolite levelswith azathioprine (19 August, 2021)
Francisca Lambert-Fliszar, Sasha Bernatsky, Fares Kalache, Louis-Pierre Grenier, Christian A Pineau, Evelyne Vinet
Development and implementation of a virtual Lupus Patient Education Event during the COVID-19 pandemic (10 March, 2021)
Mithu Maheswaranathan, Jessica A English, Melissa A Cunningham, Diane L Kamen
Assessment of SLE activity for acute clinical decision-making: use of a colour-coded threat-level approach for the non-rheumatologist (12 February, 2021)
Cindy Flower

Lupus nephritis

Original research: Development of a lupus nephritis suboptimal response prediction tool using renal histopathological and clinical laboratory variables at the time of diagnosis (24 August, 2021)
Lindsay N Helget, David J Dillon, Bethany Wolf, Laura P Parks, Sally E Self, Evelyn T Bruner, Evan E Oates, Jim C Oates
Original research: Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network (13 August, 2021)
Kristina K Deonaraine, Philip M Carlucci, Andrea Fava, Jessica Li, David Wofsy, Judith A James, Chaim Putterman, Betty Diamond, Anne Davidson, Derek M Fine, Jose Monroy-Trujillo, Mohamed G Atta, Kristin Haag, Deepak A Rao, William Apruzzese, H Michael Belmont, Peter M Izmirly, Ming Wu, Sean Connery, Fernanda Payan-Schober, Richard A Furie, Celine C Berthier, Maria Dall'Era, Kerry Cho, Diane L Kamen, Kenneth Kalunian, Jennifer Anolik, Mariko Ishimori, Michael H Weisman, The Accelerating Medicines Partnership RA/SLE network, Michelle A Petri, Jill P Buyon
Original research: Performance of the 2019 EULAR/ACR systemic lupus erythematosus classification criteria in a cohort of patients with biopsy-confirmed lupus nephritis (8 February, 2021)
Huijing Wang, Yunjie Gao, Yanhong Ma, Fanghao Cai, Xiaohan Huang, Lan Lan, Pingping Ren, Yaomin Wang, Jianghua Chen, Fei Han

Meeting report

What are the topics you care about making trials in lupus more effective? Results of an Open Space meeting of international lupus experts (20 May, 2021)
Johanna Mucke, Marta Alarcon-Riquelme, Jeanette Andersen, Martin Aringer, Stefano Bombardieri, Ralph Brinks, Ricard Cervera, Gamal Chehab, Alain Cornet, Nathalie Costedoat-Chalumeau, László Czirják, Andrea Doria, Rebecca Fischer-Betz, Richard A Furie, Mariele Gatto, Frédéric A Houssiau, Luis Ines, Matthew H Liang, Eric Morand, Marta Mosca, José María Pego-Reigosa, Iñigo Rúa-Figueroa, Guillermo Ruiz-Irastorza, Benjamin Terrier, Anne Voss, Matthias Schneider

Protocol

LUPUS-BEST—treat-to-target in systemic lupus erythematosus: study protocol for a three-armed cluster-randomised trial
(12 July, 2021)
Johanna Mucke, Oliver Kuss, Ralph Brinks, Sabine Schanze, Matthias Schneider
Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial (7 May, 2021)
Rachel L Randell, Lindsay Singler, Anthony Cunningham, Laura E Schanberg, Michael Cohen-Wolkowiez, Christoph P Hornik, Stephen J Balevic

Reproductive health and APS

Original research: Effectiveness of a multidisciplinary clinical pathway for women with systemic lupus erythematosus and/or antiphospholipid syndrome (5 May, 2021)
Merlijn Wind, Maike Hendriks, Bernadette T J van Brussel, Jeroen Eikenboom, Cornelia F Allaart, Hildo J Lamb, Hans-Marc J Siebelink, Maarten K Ninaber, Nan van Geloven, Jan M M van Lith, Tom W J Huizinga, Ton J Rabelink, Marieke Sueters, Y K Onno Teng
Original research: Breastfeeding in women with rheumatic diseases (8 April, 2021)
Naira Ikram, Amanda Eudy, Megan E B Clowse

Correction

Correction: SARS-CoV-2 vaccines in patients with SLE (17 March, 2021)

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Current Issue

January 2021 - Volume 8 - 1

Animal models

Cutaneous lupus

Brief communication

Biomarker studies

Co-morbidities

Clinical trials and drug discovery

Childhood lupus

Epidemiology and outcomes

Genetics

Immunology and inflammation

Letter

Lupus nephritis

Meeting report

Protocol

Reproductive health and APS

Correction

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Current Issue

January 2021 - Volume 8 - 1

Animal models

Cutaneous lupus

Brief communication

Biomarker studies

Co-morbidities

Clinical trials and drug discovery

Childhood lupus

Epidemiology and outcomes

Genetics

Immunology and inflammation

Letter

Lupus nephritis

Meeting report

Protocol

Reproductive health and APS

Correction