Diffuse alveolar hemorrhage (DAH) has been described in a number of systemic autoimmune diseases, including systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), Behçet’s disease, microscopic polyarteritis, cryoglobulinaemic vasculitis, Henoch-Schönlein purpura, Goodpasture’s syndrome, granulomatous vasculitis and others.1
The potential clinical importance of this complication needs to be stressed. It is likely that the true frequency is significantly higher than the very low prevalence suggested by the paucity of reported cases. Diffuse alveolar hemorrhage syndromes are notoriously difficult to diagnose. In the majority of cases, there is little or no haemoptysis, even with large volume intra-alveolar bleeding. The radiological signs are sometimes florid but often highly non-specific, consisting of amorphous ground-glass attenuation on chest radiography or high-resolution computed scans of the thorax. Invasive or semi-invasive evaluation is generally required, specifically bronchoscopy, with or without a surgical lung biopsy.
In general, in treated autoimmune diseases, infiltrative lung disorders can, for practical therapeutic purposes, be divided broadly into opportunistic infection, which demands specific antimicrobial therapy and a reduction in immunosuppression, and a wide range of immunologically mediated processes, which demand the opposite approach: intensification of immunosuppressive therapy. Refinement of the differential diagnosis in the latter group is important, but less important than the exclusion of infection. Bronchoalveolar lavage (BAL) to exclude infection has been the pivotal investigation that has allowed an empirical immunosuppressive approach. A pragmatic approach of standard immunosuppressive therapy after the exclusion of infection is not, in itself, sufficient. Active steps must be taken to diagnose DAH.2
Explain the main challenges in the differential diagnosis of alveolar hemorrhage in SLE
Describe the options for the treatment of alveolar hemorrhage in SLE
Discuss new trends in research on new markers for alveolar hemorrhage in SLE
Martínez-Martínez MU, Oostdam DAH, Abud-Mendoza C. Diffuse Alveolar Hemorrhage in Autoimmune Diseases. Curr Rheumatol Rep. 2017;19(5):27.
Asherson RA, Cervera R, Wells AU. Diffuse alveolar hemorrhage: a nonthrombotic antiphospholipid lung syndrome?Semin Arthritis Rheum. 2005;35(3):138–42.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.