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12 All lupus nephritis patients should be initially managed with both established standard therapies and the new generation drugs
  1. YK Onno Teng
  1. Leiden University Medical Center (LUMC), the Netherlands


The year 2020 has been an extraordinary year in many ways but especially for patients with lupus nephritis (LN), as 2020 saw two novel agents (belimumab and voclosporin) finding FDA-approval for the treatment of LN. These agents will both enrich the therapeutic armamentarium, allowing physicians to better treat their LN patients, as well as broaden treatment strategies that can be employed.

In this pro-con debate, I will highlight the trial data that have led to the FDA approval of belimumab and voclosporin for the treatment of LN. I will also address the unmet needs these new compounds can address in the treatment of LN. Lastly, the potential treatment strategies emerging from the approval of these new agents will be addressed.

Learning Objectives

  • Describe the evidence for the latest FDA-approved drugs for LN: Belimumab and voclosporin

  • Describe the current challenges physicians face when treating patients with LN

  • Describe possible new treatment strategies for patients with LN

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