There is little question that our colleagues in rheumatology who treat patients with rheumatoid or psoriatic arthritis have outdone us ‘lupologists’ in bringing new therapies to the community. Biologics have truly been transformative for those patients with inflammatory arthritis. We are now starting to see the same successes in lupus. As we celebrate the 10th anniversary of the FDA approval of belimumab, the lupus community recently witnessed the approval of two drugs, belimumab and voclosporin, for the treatment of lupus nephritis. In addition, several Phase 2 studies yielded favorable results and will be progressing to Phase 3.1–5 Drug development activity is currently unprecedented, and there is no doubt that research advances will improve outcomes and ensure brighter futures for our patients with systemic lupus.
Describe unmet needs in SLE treatment
Discuss biologic targets for SLE drug development
Explain recent clinical trial results
Wallace DJ, Furie RA, Tanaka Y, et al. Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial. Lancet. 2018;392(10143):222–31.
Rovin BH, Solomons N, Pendergraft WF, 3rd, et al. A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with active lupus nephritis. Kidney Int. 2019;95(1):219–31.
Furie R, Werth VP, Merola JF, et al. Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus. J Clin Invest. 2019;129(3):1359–71.
Furie R, Rovin BH, Houssiau F, et al. Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis. N Engl J Med. 2020;383(12):1117–28.
Morand EF, Furie R, Tanaka Y, et al. Trial of Anifrolumab in Active Systemic Lupus Erythematosus. N Engl J Med. 2020;382(3):211–21.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.