Article Text

Download PDFPDF

1401 Effects of anifrolumab on renal disease in patients with systemic lupus erythematosus
  1. Eric F Morand1,
  2. Richard A Furie2,
  3. Yoshiya Tanaka3,
  4. Tsutomu Takeuchi4,
  5. Gabriel Abreu5,
  6. Raj Tummala6 and
  7. Catharina Lindholm5
  1. 1Monash University, Melbourne, VIC, Australia
  2. 2Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA
  3. 3University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
  4. 4Keio University School of Medicine, Tokyo, Japan
  5. 5BioPharmaceuticals RandD, AstraZeneca, Gothenburg, Sweden
  6. 6BioPharmaceuticals RandD, AstraZeneca, Gaithersburg, MD, USA


Background The type I interferon (IFN) receptor antibody, anifrolumab, has shown efficacy in patients with systemic lupus erythematosus (SLE) in the phase 3 TULIP-1 and TULIP-2 trials. Type I IFN dysregulation is associated with lupus nephritis (LN) pathogenesis. Pooled TULIP data were analyzed to assess baseline characteristics of patients with and without renal involvement and to evaluate the effects of anifrolumab on renal disease.

Methods TULIP-1 and TULIP-2 were randomized, placebo-controlled trials of intravenous anifrolumab in patients with moderate to severe SLE despite standard therapy, which excluded patients with severe active LN. Renal involvement at baseline was defined as any of the following: British Isles Lupus Assessment Group(BILAG)-2004 renal score A–C; SLE Disease Activity Index 2000 (SLEDAI-2K) renal score >0; urine protein–creatinine ratio (UPCR) >0.5 mg/mg. Baseline characteristics were evaluated in patients with and without renal involvement, and the following endpoints were compared for the anifrolumab 300 mg and placebo groups: cumulative UPCR (area under the curve, AUC) through Week (W)52; percentage of patients with UPCR >0.5 mg/mg at baseline who improved to UPCR ≤0.5 mg/mg at W52; cumulative glucocorticoid (GC) use (AUC) through W52; and percentage changes in complement C3/C4 from baseline to W52.

Results Of the 726 patients in TULIP-1/-2 (anifrolumab, n=360; placebo, n=366), 99 had renal involvement at baseline (anifrolumab, n=45; placebo, n=54), 57 of whom had UPCR >0.5 mg/mg (anifrolumab, n=24; placebo, n=33). Patients with vs without renal involvement had a lower mean age (37.8 vs 42.4 years) and were more likely to be male (14.1% vs 6.1%), Asian (16.2% vs 9.6%), IFN gene signature high (89.9% vs 81.5%), and anti-dsDNA positive (69.7% vs 40.4%); have a SLEDAI-2K score ≥10 (91.9% vs 68.4%); and be receiving GC ≥10 mg/day (67.7% vs 49.1%) or mycophenolate (26.3% vs 11.5%) at baseline. Among patients with baseline renal involvement, anifrolumab treatment was associated with a greater improvement vs placebo in cumulative UPCR (AUC) through W52 (table 1). More patients improved from UPCR >0.5 mg/mg at baseline to ≤0.5 mg/mg at W52 with anifrolumab vs placebo (table 1). Among patients with renal involvement, cumulative GC use (AUC) through W52 was lower with anifrolumab vs placebo and there were greater improvements in C3/C4 from baseline to W52 (table 1).

Abstract 1401 Table 1

Renal endpoints in TULIP-1 and TULIP-2

Conclusions TULIP data suggest renal benefit with anifrolumab in patients with SLE with mild/stable renal disease, supporting further investigation into anifrolumab’s efficacy in patients with active LN.

Acknowledgments Writing assistance by Rosie Butler, PhD, of JK Associates Inc., part of Fishawack Health. This study was sponsored by AstraZeneca.

Trial Registration NCT02446912 and NCT02446899

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.