1703 Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing endoplasmic reticulum stress

David J Rawlings; Fahd Al Qureshah; Sara Sagadiev; Christopher D Thouvenel; Shuozhi Liu; Zhaolin Hua; Baidong Hou; Mridu Acharya; Richard G James

doi:10.1136/lupus-2021-lupus21century.98

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Abstracts

1703 Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing endoplasmic reticulum stress

Authors

David J Rawlings Seattle Children’s Research Institute, Seattle, WA, USA Departments of Immunology, University of Washington, Seattle, WA, USA Departments of Pediatrics, University of Washington, Seattle, WA, USA PubMed articles Google scholar articles
Fahd Al Qureshah Seattle Children’s Research Institute, Seattle, WA, USA Departments of Immunology, University of Washington, Seattle, WA, USA King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia PubMed articles Google scholar articles
Sara Sagadiev Seattle Children’s Research Institute, Seattle, WA, USA PubMed articles Google scholar articles
Christopher D Thouvenel Seattle Children’s Research Institute, Seattle, WA, USA PubMed articles Google scholar articles
Shuozhi Liu Seattle Children’s Research Institute, Seattle, WA, USA PubMed articles Google scholar articles
Zhaolin Hua Institute of Biophysics, Chinese Academy of Sciences, Beijing, China PubMed articles Google scholar articles
Baidong Hou Institute of Biophysics, Chinese Academy of Sciences, Beijing, China PubMed articles Google scholar articles
Mridu Acharya Seattle Children’s Research Institute, Seattle, WA, USA PubMed articles Google scholar articles
Richard G James Seattle Children’s Research Institute, Seattle, WA, USA Departments of Pediatrics, University of Washington, Seattle, WA, USA Departments of Pharmacology, University of Washington, Seattle, WA, USA PubMed articles Google scholar articles

Citation

Rawlings DJ, Qureshah FA, Sagadiev S, et al

1703 Activated PI3Kδ signals compromise plasma cell survival via limiting autophagy and increasing endoplasmic reticulum stress

Lupus Science & Medicine 2021;8:doi: 10.1136/lupus-2021-lupus21century.98

Publication history

First published November 4, 2021.

Online issue publication

January 09, 2022

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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