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Lupus nephritis
Original research
Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway

Authors

  • Xiao-cui Chen Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Dan Wu Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Hong-luan Wu Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Hui-yuan Li Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Chen Yang Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Hong-yong Su Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Ze-jian Liu Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Xiao-rong Huang Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Xing Lu Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Li-feng Huang Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Shao-ping Zhu Laboratory Animal Center, Guangdong Medical University, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Qing-jun Pan Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Ning An Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  • Hua-feng Liu Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, ChinaGuangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases co-sponsored by province and city, Zhanjiang, Guangdong, China PubMed articlesGoogle scholar articles
  1. Correspondence to Ning An; an347{at}163.com; Hua-feng Liu; hf-liu{at}263.net
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Citation

Chen X, Wu D, Wu H, et al
Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway
Lupus Science & Medicine 2022;9:e000611. doi: 10.1136/lupus-2021-000611

Publication history

  • Received November 9, 2021
  • Accepted March 30, 2022
  • First published April 12, 2022.
Online issue publication 
April 12, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.