Cytophagic histiocytic panniculitis (CHP) is considered as a localized subtype of of heamophagocytic syndrome. We present a rare association of that fatal disease with an 30 year-old SLE pregnant female presented with low grade fever, multiple erythematous nodular skin lesions on the legs and trunk, polyarthralgia hepatosplenomegaly and leukaemia. Histological examination for the skin lesion showed features of lobular panniculitis, area of fat necrosis,and non specific mixed inflammatory infiltrates with clusters of histiocytes containing phagocytosis material of red and white blood cells, and nuclear debris (bean bag cells). Although the initial clinical features simulate SLE disease activity, the histological features were consistent with cytophagic histiocytic panniculitis.
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