Purpose Systemic lupus erythematosus (SLE) is a chronic inflammatory disease, characterized by the deposition of immunocomplexes in vital organs such as the heart, brain, and kidneys. High autoantibodies titers have been associated with a worse cardiovascular prognosis. Anti-double stranded DNA (anti-dsDNA) antibody has been associated with skin, brain and kidney injury, however, information about its association with cardiovascular risk is scarce. We aimed to evaluate the association between measure anti-dsDNA antibody titers and echocardiographic parameters in SLE patients.
Methods This was a cross-sectional study. We recruited a total of 67 patients with SLE diagnosis, according to the 2019 EULAR/ACR classification criteria, aged ≥18 years. A transthoracic echocardiogram was performed by two certified echocardiographers blinded to clinical information. A blood sample was drawn to measure anti-dsDNA titers. Distribution was evaluated with the Kolmogorov-Smirnov test. Correlations between anti-dsDNA antibody titers and echocardiographic parameters were determined with Spearman’s correlation coefficient (rs). A p-value < 0.05 was considered statistically significant.
Results Median age of SLE patients was 37 (24–42) years, 89.6% were women, and 20.9% had hypertension diagnosis. Demographic and clinical characteristics are shown in Table 1. We found a moderate positive correlation between anti-dsDNA antibody titers and left ventricular mass index (rs = 0.332, p = 0.006), a moderate positive correlation between anti-dsDNA antibody titers and the ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) (rs = 0.368, p = 0.003), and a moderate positive correlation between anti-dsDNA and pulmonary arterial systolic pressure (PASP) (rs = 0.326, p = 0.013) (Table 2).
Conclusions Higher titers of anti-dsDNA antibody are associated with higher left ventricular mass index, E/e’, and PSAP, which could lead to the development of ventricular hypertrophy, diastolic dysfunction, and pulmonary hypertension respectively. The performance of a transthoracic echocardiogram may be helpful to detect early cardiovascular abnormalities in SLE patients, especially those with high anti-dsDNA antibody titers.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.